Sercan YILMAZ, Ali YILDIZ, Serdar YALÇIN, Can SİCİMLİ, Ali Fuat ÇİÇEK, Bahadır TOPUZ, Selahattin BEDİR

Genç populasyonda mesane tümörlerinin klinik ve patolojik özellikleri

Amaç: Mesane kanserinin çocuklarda ve genç eriskinlerde görülme prevalansı ise %1’den azdır. Genç populasyonda görülen mesane kanserinin klinik davranışıyla ilgili literatürde yeterli kanıt bulunmamaktadır. Bu çalışmadaki amacımız; kliniğimizde 40 yaş altındaki hastalarda görülen mesane tümörlerinin klinik seyrini ve histopatolojik özelliklerini değerlendirmekti. Gereç ve Yöntemler 2000-2020 yılları arasında kliniğimizde mesane neoplazisi tanısı alarak opere edilmiş hastaların klinik ve histopatolojik verileri retrospektif olarak incelendi. Tümörün histopatolojisi, anatomik topografisi, evresi, derecesi, hastaya uygulanan tedavi, risk faktörleri, tümör rekürrensi, progresyonu ve ortalama takip süreleri kayıt altına alındı. Bulgular Çalışmaya toplam 88 hasta dahil edildi. Histopatolojik sonuçlar değerlendirildiğinde hastaların %51.1’inin malign raporlandığı gözlendi. Papiller ürotelyal karsinoma ise en sık gözlenen ürotelial karsinoma alt tipi olarak dikkat çekti. Değişici epitel hücreli mesane kanseri olan hastaların %97.7’sinde Ta, %95.3’ünde düşük dereceli tümör mevcuttu. Tüm hastalar gözönüne alındığında nüks oranı %23.8, progresyon oranı ise %14.2 olarak hesaplandı. Sonuç Genç yaşta teşhis edilen mesane tümörleri düşük patolojik evrede olma eğilimindedir ve nispeten düşük nüks, progresyon oranları vardır. Bu nedenle; bu yaş grubundaki hastalarda daha konservatif yaklaşımlar tercih edilmeli ve tedavi sonrası yakın bir şekilde takip edilmelidir.

Anahtar Kelimeler:

genç, kanser, mesane, neoplazm

Clinical and pathological features of bladder tumors in the young population

Introduction The prevalence of bladder cancer in children and young adults is less than 1%. There is not enough evidence about clinical behavior of bladder cancer in younger patients. Our aim in this study; To evaluate the clinical behaviour and histopathological features of bladder tumors in patients under 40 years old in our clinic. Histopathology, anatomical topography, stage, grade, treatment, risk factors, tumor recurrence, progression and mean follow-up times were recorded. Material and methods The clinical and histopathological data of the patients who were operated in our clinic between 2000-2020 with the diagnosis of bladder neoplasia were analyzed retrospectively. Results A total of 88 patients were included in the study. When histopathological results were evaluated, 51.1% of patients were reported to be malignant. Papillary urothelial carcinoma was the most common subtype of urotelial carcinoma. There was Ta tumor in 97.7%, low grade tumor in 95.3% of patients with transitional cell bladder cancer. When we consider all of the patients, the recurrence rate was 23.8%, and the progression rate was 14.2%. Conclusion Bladder tumors diagnosed at young age tend to be at a low pathological stage and have relatively low recurrence, progression rates. Therefore; more conservative approaches should be preferred in patients in this age group and should be followed up closely after treatment.

Keywords:

bladder, cancer, neoplasm, young,

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