Fentanil ve Remifentanil’in perkütan nefrolitotomi vakalarında inraoperatif hemodinami ve postoperatif derlenmeye etkileri

Amaç: Perkütan nefrolitotomi (PCNL) uygulanan hastalarda fentanil veya remifentanilin intraoperatif hemodinamik etkileri ve postoperatif derlenme üzerine etkilerini karşılaştırmak.Gereç ve Yöntemler: Çalışmamız randomize, ve prospektif olarak yapıldı. Çalışmaya Amerikan Anestezist Derneği (ASA) I-II ile PCNL uygulanan 40 hasta dahil edildi. Uygulanan anestezi tekniği aynı olup remifentanil-fentanil ilaç kullanımına göre tüm hastalar 2 gruba ayrıldı. Her iki grupta anestezi indüksiyonu bolus dozda propofol 2mg/kg ile idame sevofluran (MAC 2) ile sağlandı. Kas gevşemesi 0,6 mg/kg rokuronyum ile elde edildi. Grup 1’e anestezi indüksiyonu sırasında tek doz halinde 1 μgr/kg remifentanil, Grup 2’ye anestezi indüksiyonu sırasında tek doz olarak fentanil 2µg/kg verildi. Hemodinamik stabiliteyi sağlamak amaçlı Grup 1’de remifentanil infüzyon şeklinde (0.05 μg/kg/dk.), grup 2’de ise 45 dk. da bir fentanil 0,5 μg/kg iv puşe verildi. İntraoperatif hemodinamik parametreler ve iyileşme verileri kaydedildi. Aldrete Skoru, Ramsay Sedasyon Skalasında 15, 60, 360. dakikalardaki değerler ameliyat sonrası kaydedildi. Ağrı değerlendirmesi için görsel analog skala (VAS0-10) kullanıldı.Bulgular: İntraoperatif hemodinamik ölçümler Grup 1’de daha stabildi. Nitro-gliserin ihtiyacı Grup 2’de anlamlı olarak arttı (p <0,05). Aldrete skorları, Ramsay sedasyon ölçekleri ve VAS gruplar arasında anlamlı farklılık göstermedi. Derlenme Grup 1’de Grup 2’den anlamlı olarak erkendi (p<0,05).Sonuç: PCNL sırasında fentanile kıyasla Remifentanil ile stabil hemodinamik durum ve daha güvenli iyileşme sağlanabilir.

Effects of Fentanyl and Remifentanil on intraoperative hemodynamics and postoperative recovery in percutaneous nephrolithotomy cases

Objective: To compare the effects of fentanyl or remifentanil on intraoperative hemodynamic effects and postoperative recovery in patients undergoing percutaneous nephrolithotomy (PCNL).Material and Methods: Randomized and prospective study was conducted. Forty patients who underwent PCNL with the American Society of Anaesthesiologists (ASA) I-II enrolled into the study. All patients were divided into 2 groups according to administered anaesthesiology technique and drugs, which are remifentanil and fentanyl. Induction of anesthesia was same in both groups. Induction of anesthesia was obtained with a bolus dose of propofol (1-2 mg/kg), maintenance was achieved with sevoflurane (MAC2). Muscle relaxation was achieved with rocuronium. Group 1 was consisted of patients who were administered remifentanil and they received 1 μgr/kg of remifentanil as a single dose during the induction of anaesthesia Group 2 was received fentanyl 2 μg/kg as a single dose during the induction of anaesthesia. Group 1 received remifentanil 0.05 μgr/kg per minute as an infusion throughout the procedure for providing intraoperative hemodynamic stability, in group 2 fentanyl was given at a dose of 0.5 μg/kg iv bolus every 45 minutes. Intraoperative hemodynamic parameters and recovery data were recorded. Aldrete score, Ramsay sedation scale 15, 60, 360 minutes were noted after surgery. Visual analogue scale (VAS0-10) was used for pain evaluation.Results: Intraoperative hemodynamic measurements were more stable in Group 1. The need for nitro-glycerine was significantly increased in Group 2 (p<0.05). The Aldrete scores, Ramsay sedation scales and VAS did not differ significantly between the groups. Immediate recovery was significiantly earlier in Group 1 than Group 2 (p<0.05).Conclusion: Stable hemodynamic status and safer recovery can be provided with remifentanil compared to fentanyl during PCNL.

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