Sigara kullanımının ülseratif kolitte total rektum duvar kalınlığı üzerine etkisi olabilir mi?

Giriş ve Amaç: Ülseratif kolit idiyopatik, relapslarla seyreden kronik inflamatuvar bir hastalıktır. Sigara kullanımı ülseratif kolit gelişiminde ve progresyonunda etkilidir. Amacımız sigara kullanım öyküsü olan ülseratif kolitlilerde total rektal duvar kalınlığını değerlendirmekti. Gereç ve Yöntem: Çalışmaya 19 ülseratif kolitli hasta ve 19 kişilik kontrol gurubu alındı. Transrektal ultrasonografi ile total rektal duvar kalınlığı, ülseratif kolit gurubu ile kontrol gurubu arasında karşılaştırıldı. Ülseratif kolit gurubunda total rektal duvar kalınlığını belirgin olarak artmış saptadık. Daha sonra ülseratif kolit ve kontrol gurupları içinde total rektal duvar kalınlığını sigara içme öyküsü olanlarla olmayanlar arasında karşılaştırdık. Bulgular: Çalışmamıza 19 ülseratif kolit li hasta (4 kadın/15 erkek, ortalama yaş 46.8±13.3) ve 19 kontrol (5 kadın/14 erkek, 46.6±11.8) alındı. Ülseratif kolitlilerin 9’unda hastalık aktifken, 10’u remisyondaydı. Total rektal duvar kalınlığını ülseratif kolit’lilerde kontrollere göre artmış olarak saptadık, median sırasıyla [4.1 mm (3.1-4.6)]’ye karşın [2.5 mm (2.0-3.7)] (P=0.003). Ek olarak, total rektal duvar kalınlığı sigara öyküsü olan ülseratif kolit hastalarında sigara öyküsü olmayanlara göre belirgin olarak arttığını saptadık, sırasıyla median [4.6 mm (4.3-4.9)]’ye karşın [3.8 mm (2.6-4.1)] (P=0.025). Kontrol gurubunda ise sigara kullanım öyküsüne göre total rektal duvar kalınlığında farklılık yoktu. Sonuç: Sigara kullanım öyküsü olan ülseratif kolitlilerde transrektal ultrasonografi ile total rektal duvar kalınlığını artmış olarak saptadık.

Anahtar Kelimeler:

Transrektal ultrasonografi, ülseratif kolit

Can smoking have an effect on total rectum wall thickness in ulcerative colitis?

Background and Aims: Ulcerative colitis is an idiopathic, chronic inflammatory disease with a high relapse rate. Smoking contributes to the development and progression of ulcerative colitis. We determined total rectal wall thickness in patients with ulcerative colitis who had a smoking history. Materials and Methods: We included 19 patients with ulcerative colitis (ulcerative colitis group) and 19 controls (control group) and compared total rectal wall thickness among them. Total rectal wall thickness was significantly greater in the ulcerative colitis group. We also compared total rectal wall thickness between patients with and without smoking history in both groups. Results: Of the 19 patients with ulcerative colitis, 4 and 15 were females and males, respectively, with a mean age of 46.8±13.3 years. Of the 19 controls, 5 and 14 were females and males, respectively, with a mean age of 46.6±11.8 years. While 9 patients with ulcerative colitis were active, 10 were in remission. The median (interquartile range) total rectal wall thickness was significantly higher in the ulcerative colitis group (4.1 mm [3.1–4.6]) than in the control group (2.5 mm [2.0-3.7]) (p=0.003). The median total rectal wall thickness was significantly higher in patients with ulcerative colitis and a smoking history than in those without (4.6 mm [4.3-4.9] vs. 3.8 mm [2.6-4.1], respectively; p=0.025). Total rectal wall thickness did not differ according to smoking history in the control group. Conclusion: Smoking history is associated with total rectal wall thickness increase patients with ulcerative colitis on transrectal ultrasonography.

Keywords:

Transrectal ultrasonography ulcerative colitis, cigarette smoking,

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