Kırım Kongo kanamalı ateşine H. pylorivarlığının etkisi

Giriş ve Amaç:Kırım Kongo kanamalı ateşi ölümcül hemorajik bir sendroma neden olabilir. Bu çalışmada Helicobacter pylori varlığının Kırım Kongo kanamalı ateşi hastalığının şiddeti ya da kanama üzerine etkisinin olup olmadığını araştırdık. Gereç ve Yöntem:Kırım Kongo kanamalı ateşi nedeniyle Nisan 2009-Temmuz 2009 arası hospitalize edilen kırk iki dispeptik hasta çalışmaya dahil edildi. Hastalar fekal Helicobacter pylori antijeni pozitifliği durumuna göre iki gruba ayrıldı. Her iki grupta Kırım Kongo kanamalı ate-şi'nin klinik ve labaratuvar olarak şiddet kriterleri değerlendirildi. Bulgular: Klinik ve laboratuvar kriterleri açısından iki grup arasında Kırım Kongo kanamalı ateşi hastalık şiddeti açısından farklılık saptanmadı. Sonuç: Bu çalış-ma Helicobacter pylori'nin Kırım Kongo kanamalı ateşi'nin şiddeti üzerine etkisini araştıran ilk çalışma olması ve hem Helicobacter pylori hem de Kırım Kongo kanamalı ateşi'nin endemik olduğu bir bölgeden yapılması nedeniyle önemlidir. Ancak Kırım Kongo kanamalı ateşi hastalarında rutin Helicobacter pylori taranması ve eradikasyonunun önerilebilmesi için daha geniş vaka sayılı çalışmalara ihtiyaç vardır.

Effect of H. pyloripresence on the severity of Crimean Congo hemorrhagic fever

Background and Aims:Crimean Congo hemorrhagic fever can cause a fatal hemorrhagic syndrome. We aimed to investigate whether the presence of Helicobacter pylori increases the bleeding or severity of Crimean Congo hemorrhagic fever. Materials and Methods:Forty-two patients with Crimean Congo hemorrhagic fever who had dyspepsia and were hospitalized between April 2009 and July 2009 were included in the study. The patients were divided into two groups according to their fecal Helicobacter pylori antigen positivity. Clinical and laboratory severity criteria for Crimean Congo hemorrhagic fever were investigated in both groups. Results:We could not find any difference between the two groups with regard to severity as defined by clinical and laboratory criteria. Conclusion: This is the first study in the literature investigating the role of Helicobacter pylori in the severity of Crimean Congo hemorrhagic fever from a country in which both Crimean Congo hemorrhagic fever and Helicobacter pylori are endemic. Further studies including a larger number of Crimean Congo hemorrhagic fever patients are necessary to recommend Helicobacter pylori screening and eradication in Crimean Congo hemorrhagic fever.

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  • Ergonul O, Celikbas A, Baykam N, et al. Analysis of risk-factors among patients with Crimean-Congo haemorrhagic fever virus infection: sever- ity criteria revisited. Clin Microbiol Infect 2006; 12: 551-4.
  • Franchini M, Veneri D. Helicobacter pylori infection and immune thrombocytopenic purpura: an update. Helicobacter 2004; 9: 342-6.
  • Onguru P, Dagdas S, Bodur H, et al. Coagulopathy parameters in pa- tients with Crimean-Congo hemorrhagic fever and its relation with mor- tality. J Clin Lab Anal 2010; 24: 163-6.
  • Yilmaz G, Koksal I, Topbas M, et al. The effectiveness of routine labora- tory findings in determining disease severity in patients with Crimean- Congo hemorrhagic fever: severity prediction criteria. J Clin Virol 2010; 47: 361-5.
  • Yilmaz GR, Buzgan T, Irmak H, et al. The epidemiology of Crimean- Congo hemorrhagic fever in Turkey, 2002–2007. Int J Infect Dis 2008; 13: 380–6.
  • Cevik MA, Erbay A, Bodur H, et al. Clinical and laboratory features of Crimean-Congo hemorrhagic fever: predictors of fatality. Int J Infect Dis 2008; 12: 374-9.
  • Gunes T, Engin A, Poyraz O, et al. Crimean-Congo hemorrhagic fever virus in high-risk population, Turkey. Emerg Infect Dis 2009; 15: 461-4.
  • Whitehouse CA. Crimean-Congo hemorrhagic fever. Antiviral Res 2004; 64: 145-60.
  • Choe BH, Kim JY, Lee JH, et al. Upper gastrointestinal bleeding in chil- dren with haemophilia: a clinical significance of Helicobacter pylori in- fection. Haemophilia 2010; 16: 277-80.
  • Abasiyanik MF, Tunc M, Salih BA. Enzyme immunoassay and immu- noblotting analysis of Helicobacter pylori infection in Turkish asymp- tomatic subjects. Diag Microbio Infect Dis 2004; 50: 173–7.
  • Jackson S, Beck PL, Pineo GF, et al. Helicobacter pylori eradication: novel therapy for immune thrombocytopenic purpura? A review of the literature. Am J Hematol 2005; 78: 142-50.