İlaca bağlı özofajit: İnsidans, klinik ve endokospik bulgular ve yönetimi
Giriş ve Amaç: İlaca bağlı özofajit nadir görülen bir antite olup, değişik derecede klinik ve özofagogastroduodonoskopik bulgularla prezente olur. Bir yıllık periodda görülme sıklığı, klinik ve gastroskopik özelliklerin incelenmesi amaçlanmıştır. Gereç ve Yöntem: Şubat 2010-Şubat 2011 yılları arasında Erzurum Eğitim ve Araştırma Hastanesinde gastroskopisi yapılan 4185 hastada, ilaca bağlı özofajit saptanan hastalar prospektif olarak takip edildi. Bulgular: Özofagogastroduodonoskopik yapılan hastaların yaş ortalamsı 47.8±18.1 (dağılım 12-100) yaş olup, 1926 (%46)’sı erkekti. Hastaların 760 tanesinde (%18) özofajit saptandı. Hastaların 5 tanesinde (özofagogastroduodonoskopik yapılanların %0.012’si, özofajitlerin %0.65’i) ilaca bağlı özofajit tesbit edildi. Tüm hastaların retrosternal ağrı, disfaji ve odinofaji yakınmaları vardı. Bu hastaların 4 tanesi genç kadın, 1 tanesi yaşlı erkek olup, hastalara doksisiklin, tetrasiklin ve tramodol hidroklorür alım hikayeleri ve gastroskopi bulguları ile tanı konuldu. Tanı konulduktan sonra sebeb olan ilaçlar kesilerek, enteral veya parenteral proton pompa inhibitörü başlandı. Takiplerde hiçbir hastada komplikasyon gelişmedi. Sonuç: İlaca bağlı özofajit sık görülen biri klinik antite olmayıp, hastalar değişik derecelerde özofagogastroduodonoskopik bulgularla, bazen ciddi özofajitle prezente olur. Sebep olan ilacın kesilmesi ve proton pompa inhibitörü tedavisi yeterli olmaktadır.
Anahtar Kelimeler:
İlaca bağlı özofajit, insidans, tedavi
Drug-induced esophagitis: Incidence, clinical and endoscopic findings, and management
Background and Aims: Drug-induced esophagitis is a rare condition, which presents with varying severity in terms of clinical and gastroscopic findings. This study aimed to investigate the incidence, clinical and endoscopic findings, and management of the disease in a prospective 1-year follow-up period. Materials and Methods: Overall, 4185 patients underwent esophagogastroduodenoscopy at the Endoscopy Unit of Erzurum Education and Research Hospital between February 2010 and February 2011. Among these, the patients diagnosed with drug-induced esophagitis were followed up prospectively. Results: Among patients who underwent esophagogastroduodenoscopy, 1926 (46%) were males with a mean age of 47.8±18.1 years (range, 12–100 years). In total, 760 patients (18%) were diagnosed with esophagitis, of which five had drug-induced esophagitis (0.012% of gastroscopies, 0.65% of esophagitis). All patients presented with symptoms of retrosternal pain, odynophagia, and dysphagia. Four patients were young women, whereas the remaining patient was an elderly man; based on the medical history and esophagogastroduodenoscopy findings, patients diagnosed with esophagitis were using doxycycline, tetracycline, and tramadol hydrochloride capsules. Drugs that were considered to be the causative agents of esophagitis were discontinued, and proton pump inhibitors were administered parenterally or orally. The patients recovered without any complications. Conclusion: Drug-induced esophagitis is considered to be a rare condition, presenting with varying esophagogastroduodenoscopy findings and severe esophagitis in some cases. Discontinuing the causative agent and administering proton pump inhibitors are sufficient to manage the condition.
Keywords:
Drug-induced esophagitis, incidence, treatment,
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- ISSN: 1302-5422
- Başlangıç: 2010
- Yayıncı: Türk Gastroenteroloji Vakfı
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