Evre 2 kolon tümörlerinde klinikopatolojik faktörlerin sağkalımla ilişkisi

Giriş ve Amaç: Kolorektal kanserler tüm dünyada ve ülkemizde sindirim sistemi kanserlerinin başında gelmektedir. Kolorektal kanserlerin prognozunu etkileyen ve tedavide değişikliğe yol açan birçok prognostik faktör bulunmaktadır. Bu prognostik faktörler hem genel sağkalımı hem de hastalıksız sağkalımı etkilediği gibi bazıları tedavinin takibinde de kullanılabilmektedir. Çalışmamızda kolorektal kanserin prognozunu etkileyen klinikopatolojik faktörlerin genel ve hastalıksız sağ kalım üzerine olan etkilerinin gösterilmesi planlanmıştır. Gereç ve Yöntem: Ocak 2000-Aralık 2014 arasında Kartal Dr. Lütfi Kırdar Eğitim ve Araştırma Hastanesi Tıbbi Onkoloji Polikliniğine başvuran ardışık 277 evre 2 kolorektal kanserli hasta çalışmaya alınmıştır. Hastalar histopatolojik verilerine göre değerlendirilmiş ve poliklinik ve patolojik kayıtları incelenerek hastalıksız sağ kalım ve genel sağ kalım süreleri belirlenmiştir. Bulgular: Çalışmaya 159 (%57.4) erkek 118 (%42.6) kadın olmak üzere toplam 277 kişi dahil edildi. Hastaların medyan yaşı 60 (aralık 28-89) idi. 277 hastanın medyan sağkalım süresi 21 (aralık 1-184) aydı. Sonuç: Perinöral invazyon ve tanı anındaki T evresinin genel sağkalım üzerine istatistiksel etkisi olduğu izlenirken; lenfovasküler invazyon, perinörel invazyon, T evresi, tümör yerleşimi ve obstrüksiyon varlığının hastalıksız sağkalım üzerine istatistiksel etkisi olduğu görüldü.

Anahtar Kelimeler:

Evre 2 kolon tümörleri, genel sağkalım, hastalıksız sağkalım

Relationship between clinicopathological factors and prognosis in stage 2 colon cancer

Background and Aims: Colorectal cancer is the leading cancer of the digestive system affecting people worldwide. There are several prognostic factors that influence the prognosis of colorectal cancers and demonstrate changes with treatment. These prognostic factors affect both the overall and disease-free survival, some of which can be applied in the treatment follow-up. Here, we investigated the effects of clinicopathological factors on the overall and disease-free survival of patients that affected the prognosis of colorectal cancer. Material and Methods: We included 277 consecutive patients with stage 2 colorectal cancer admitted to the Kartal Dr. Lütfi Kırdar Training and Research Hospital Medical Oncology Outpatient Clinic between January 2000 and December 2014. The study patients were evaluated according to their histopathological data, and their disease-free and overall survival periods were determined by examining the outpatient and pathological medical records. Results: Of the 277 study subjects, 159 (57.4%) were men and 118 (42.6%) were women of a median age 60 years (age range: 28-89 years). The median survival time of the patients was 21 (range: 1-184) months. Conclusion: We observed that the T-stage at the time of diagnosis and perineural invasion had a statistical effect on the overall survival and that lymphovascular invasion, peripheral invasion, T-stage, tumor placement, and obstruction trait had statistical effects on the disease-free survival. Keywords: , , disease-free survival

Keywords:

Stage 2 colon tumors, overall survival,

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