Gönül ŞAHİN, Sonia SANAJOU, Reihaneh BEHNOUSH, Ehsan BAHRAMZADE

9374

Adsorption of iron, lead, paracetamol, imipramine on natural polymers

Adsorption of iron, lead, paracetamol, imipramine on natural polymers

Poisoning results from many reasons such as misuse or overdose of drugs. Suicidal and murder purposes are mostly severe, serious and life-threatening cases which require immediate intervention and treatment. Among lifesaving methods external and/or internal decontamination is the most important. Internal decontamination (gastrointestinal) is an effective process for intoxication control that can be done by adsorptive materials. Activated charcoal is used as unique local antidote for adsorption of causative agent. Considering their significance and effectiveness, adsorptive materials are necessary to be developed. In the present study, starch and naturally extracted pectin from citrus, in the presence of trace amount of potassium per sulphate as initiator, were thermally grafted to chitosan to form natural, inert, and highly adsorptive polymeric surfaces. This polymer is convenient for   biomedical purposes. Upon drying at 37°C for 48 hours, thermally cross-linked products were obtained. FTIR, UV-Visible spectrophotometer and SEM analyses were applied in order to characterize the products. To evaluate the adsorption potency of new adsorptive material, lead and iron which cause common poisoning were applied on the polymers. The results showed that adsorption degree of lead and iron were maximum 50% and 30% respectively. Desorption amounts can be a sign of adsorption potency. In this study, paracetamol and imipramine, which are commonly used drugs that can and caused intoxication in case they are misused or use for suicidal purpose were applied onto two polymers which contain pectin desorption amount for two drugs were determined. SEM pictures taken before and after blood/polymer contact didn’t reveal any significant blood component attachment on the chitosan-graft- (starch; pectin) film surface. Indicating no hemocompatibility.
Keywords:

Chitosan, decontamination, hemocompatibility, imipramine, iron lead, paracetamol, pectin, starch,

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EMU Journal of Pharmaceutical Sciences-Cover
  • ISSN: 2651-3587
  • Başlangıç: 2018
  • Yayıncı: Doğu Akdeniz Üniversitesi
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