Gülruh BÜBERAL, BANU SARSIK KUMBARACI, ADNAN ŞİMŞİR, SADIK TAMSEL, SAİT ŞEN

Primary carcinoid tumor of the testis: A rare case

Neuroendocrine tumors most commonly occur in the gastrointestinal tract, lungs and pancreas. Primary testicular neuroendocrine tumors are rare, constituting 0.23% of all testicular tumors. A 35-year-old man presented to urology department with a painless left scrotal mass. He had no history of trauma. Scrotal Doppler ultrasonography revealed a 2×1.5 cm, well-circumscribed, solid lesion. Tumor marker levels were normal and staging computed tomography demonstrated no evidence of metastasis. The patient subsequently underwent left radical orchiectomy. The orchiectomy material, grossly showed a 1.4x1.2 cm, well-circumscribed, yellow, solid mass. On histopathologic examination, primary testicular carcinoid tumors cannot be distinguished from well-differentiated neuroendocrine carcinoma. The diagnosis of a primary testicular carcinoid tumor was made after ruling out an extratesticular neuroendocrine tumor using clinical and radiological data. This rare case is presented with clinical, morphological and immunohistochemical features.

Testisin karsinoid tümörü: Nadir bir olgu

Nöroendokrin tümörler, sıklıkla gastrointestinal sistem, akciğer ve pankreas gibi organlarda görülmektedir. Primer testiküler nöroendokrin tümörler son derece nadir olup, tüm testis tümörlerinin %0.23’ünü oluşturur. 35 yaşındaki hasta, sol skrotumda ağrısız şişlik şikayeti ile üroloji kliniğine başvurdu. Hastada travma hikayesi bulunmamaktaydı. Skrotal Doppler ultrasonograsinde sol testis alt polde 2x1.5 cm boyutlarında düzgün sınırlı solid kitle izlendi. Tümör markerları ve bilgisayar tomografi taramaları normaldi ve hastada metastaz izlenmedi. Hastaya sol radikal orşiektomi uygulandı. Orşiektomi materyali, makroskobik olarak 1.4x1.2 cm boyutlarda düzgün sınırlı, sarı solid kitle olarak izlendi. Histopatolojik incelemede primer testiküler karsinoid tümör, iyi diferansiye nöroendokrin karsinomdan ayırt edilemedi. Primer testiküler karsinoid tümör tanısı, klinik ve radyolojik olarak ekstratestiküler nöroendokrin tümör dışlanarak yapıldı. Bu nadir olgu, morfolojik ve immunhistokimyasal özellikleri ile sunulmuştur.

PDF

___

10. Neely D, Gray S: Primary carcinoid tumour of the testis. Ulster Med J 2011;80(2):79-81.

9. Wang WP, Guo C, Berney DM, et al. Primary carcinoid tumors of the testis: A clinicopathologic study of 29 cases. Am J Surg Pathol 2010;34(4):519-24.

8. Bosman FT CF, Hruban RH, Theise ND. World Health Organization (WHO) Classification of Tumours of the Digestive System. 4th ed. Geneva; WHO Press; 2010:102-107.

7. Rindi G, Klöppel G, Alhman H, et al. TNM staging of foregut (neuro)endocrine tumors: A consensus proposal including a grading system. Virchows Arch 2006;449(4):395-401.

6. Davidoff MS, Schulze W, Middendorff R, Holstein AF. The Leydig cell of the human testis--a new member of the diffuse neuroendocrine system. Cell Tissue Res 1993;271(3):429-39.

5. Mai K, Park P, Yazdi H, Carlier M. Leydig cell origin of testicular carcinoid tumor: immunohistochemical and electron microscopic evidence. Histopathology 2006;49(5):548-9.

4. Abbosh PH, Zhang S, Maclennan GT, et al. Germ cell origin of testicular carcinoid tumors. Clin Cancer Res 2008;14(5):1393-6.

3. Lubana SS, Singh N, Chan HC, Heimann D. Primary neuroendocrine tumor (carcinoid tumor) of the testis: A case report with review of literature. Am J Case Rep 2015;31(16):328-32.

2. Simon HB, McDonald JR, Culp OS. Argentaffin tumor (carcinoid) occurring in a benign cystic teratoma of the testicle. J Urol 1954;72(5):892-4.

1. Langhans T. Ueber einen drusenpolyp im ileum. Virchows Arch 1867;38:559-60.