Kognitif tarama testi Cognistat'ın Türkçe'ye uyarlanması, standardizasyonu ve Alzheimer demanslı olgularda uygulanması

Amaç: Bu çalışmada Cognistat Kognitif Tarama Testinin standardizasyonu ve Alzheimer hastalarında “Mini Mental Durum Testi” ile karşılaştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmaya doksan üç normal kontrol ve seksen altı Alzheimer hastası alınmıştır. Tüm olgulara Cognistat ve Mini Mental Durum Testi uygulanmıştır. Hasta grubunda ayrıca Global Bozulma Ölçeği uygulanmıştır. Gruplar arası karşılaştırmalar yapılmıştır. Bulgular: Cognistat tarama testinin normal popülasyonda ve Alzheimer olgularında güvenilir ve Mini Mental Durum Testine oranla, yürütücü işlevler, yapılandırma ve yargılama alanlarında daha üstün olduğu gösterilmiştir. Sonuç: Cognistat tarama testi frontal işlevleri değerlendirme de Mini Mental Durum Testinden daha güvenilirdir.

Anahtar Kelimeler:

Nörodavranışsal belirtiler, Alzheimer hastalığı, Mental durum ölçeği

Turkish version of the cognitive screening test Cognistat, standardization and implementation in patients with Alzheimer dementia

Aim: To standardize Cognistat Cognitive Screening Test (CCST) in healthy controls and patients with Alzheimer's disease (AD) and compare the results with the results of the Mini Mental Status Examination (MMSE). Materials and Methods: Ninety-three healthy controls and 86 patients with AD were included in the study. All patients were examined with the Cognistat Cognitive Screening Test and Mini Mental Status Examination in addition to the Global Deterioration Scale. Results: The CCST proved to be superior to MMSE in order to evaluate executive functions, construction and judgment in both healthy controls and patients with AD. Conclusion: The CCST can be used to assess frontal functions more reliably than the MMSE.

Keywords:

Neurobehavioral Manifestations, Alzheimer Disease, Mental Status Schedule,

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1) Barnes DE, Yaffe K. The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurol 2011;10 (9):819-828.
2) Kayatekin MS, Öztürk MO, Savaşır I. Kısa kognitif muayene (KKM) çizelgesinin güvenirlik ve geçerlilik çalışmaları. Düşünen Adam. Psikiyatri ve Nörolojik Bilimler Dergisi 1986;1(6):63-66.
3) Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12(3):189-198.
4) Güngen C, Ertan T, Eker E, Yaşar R, F Engin F. Standardize mini mental test'in Türk toplumunda hafif demans tanısında geçerlik ve güvenilirliği. Türk Psikiyatri Dergisi 2002;13(4):273-281.
5) Ertan T, Eker E, Güngen C ve ark. The Standardized Mini Mental State Examination for illiterate Turkish elderly population. 2nd International Symposium on Neurophysiological and Neuropsychological Assessment of Mental and Behavioral Disorders, 28-30 Ağustos 1999, Bursa.
6) Kiernan, R.J., Mueller J., Langston J.W., Van Dyke C. The Neurobehavioral cognitive status examination, a brief but differentiated approach to cognitive assessment. Ann Int Med 1987;107:481-485.
7) Reisberg B, Ferris SH, Leon MJ, et al. The global deterioration scale for assessment of primary degenerative dementia. Am J Psychiat 1982;139:1136-1139.
8) McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34(7):939-944.
9) Crook T, Bartus RT, Ferris SH, Whitehouse P, Cohen GD, Gershon S. Age-associated memory impairment: proposed diagnostic criteria and measures of clinical change. Report of a National Institute of Mental Health Work Group. Developmental Neuropsychology 1986;2:261-276.
10) Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 1999;56(3):303-308.
11) Lezak MD. Neuropsychological Assessment. 3rd ed. New York: Oxford University Press; 1995.
12) Blessed G, Tomlinson BE, Roth M. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry 1968;114:797-811.
13) Squire LR, Schacter DL. Neuropsychology of Memory. 3rd ed. New York: The Guilford Press; 2002.
14) Strub RL, Black FW. The Mental Status Examination in Neurology. 4th ed. Philadelphia: FA Davis Company; 2000.
15) CummingsJL. Neuropsychiatry of Alzheimer’s Disease and Related Dementias. London: Martin Dunitz; 2004.
16) Stricks L, Pittman J, Jacobs DM, Sano M, Stern Y. Normative data for a brief neuropsychological battery administered to English- and Spanish-speaking community-dwelling elders. J Int Neuropsych Soc 1998;4:311-318.
17) Birren JE, Schaie KW. Handbook of the Psychology of Aging. 6th ed. San Diego: Elsevier; 2006.
18) Albert M, Knoefel J. Clinical Neurology of Aging. 3rd ed. New York: Oxford University Press; 2010.