SUMMARYAim: Propofol is a sedative-hypnotic drug with rapidonset and recovery time. There are limited number of studies in which propofol was use for bronchoscopy. In this current study, we evaluated our patients who received propofol sedation for bronchoscopy in our clinic and explored the usefulness of the  procedure for both  patients and doctors.Method: We prospectively evaluated patients who had bronchoscopy in our clinic between 2012 and 2013.  We recorded demographic features, indications for bronchoscopy, procedures of bronchoscopy, duration of the procedures, minor and major adverse events and hemodynamic parameters of the patients. All patients were monitored until they were discharged from the bronchoscopy unit.Results: In total, 97 patients were included in the study. The mean age of the participants  was 65 years, 60 of them were male (61%) and 37 were women (39%).Majorindications were lung lesions that were suspected to be central or peripheral lung cancer. Other indications were mediastinal-hilar lymph nodes, hemoptysis, tuberculosis, atelectasis, chronic cough and tracheomalacia. Mean Propofol dose was 90 mg in patients who had biopsy and 70 mg for thosewho did not have biopsy. Mean duration of the procedure was 14 minutes in those had biopsy and 10 minutes in those did not have biopsy.  One patient had epistaxis after receiving topical lidocaine and two patients had respiratory arrest that required ambulation with a mask.Thirty-five patients (36%) had desaturation, which was reversed by providing radequate oxygenation.Conclusion: Propofol is a useful and applicable sedative-hypnotic for patients and physicians.