Pınar KADİROĞULLARI, Hüseyin KIYAK, Erkan ŞİMŞEK, Emine KARABÜK, Kerem SEÇKİN

The Levels of CRP in Non-Complicated Patients With Total Laparoscopic Hysterectomy and its Role in Predicting Vaginal Cuff Hematoma

We aimed to evaluate the mean C-reactive protein (CRP) levels in the patients who did not have any complications other than cuff hematoma after total laparoscopic hysterectomy (TLH) in order to determine the CRP levels to predict the potential to develop postoperative cuff hematoma.The study was designed prospectively. The CRP levels, white blood cell (WBC) count, and haemoglobin values (Hb) of 106 patients, who underwent TLH for benign reasons, were measured preoperatively and on the days 1,2 and 7 postoperatively. The laboratory parameters of the patients who developed postoperative cuff hematoma were compared to those of the patients, who did not have any complications. Of a total of 106 patients who underwent a laparoscopic hysterectomy, there were no differences in the demographic characteristics between the groups. The duration of operation was significantly longer in the group of patients with cuff hematoma (p

PDF

___

1. Dabrows a AM, otwin ski R. The immune response to surgery and infection. Cent Eur J Immunol 2014; 39: 532-537.

2. Kim TK, Yoon JR. Comparison of the neuroendocrine and inflammatory responses after laparoscopic and abdominal hysterectomy. Korean J Anesthesiol 2010; 59: 265-269.

3. Cmickshank AIr1, Fraser WD, Burns HJG, et al. Response of serum interleukin-6 in patients undergoing elective surgery of varying severity. Clin Sci 1990; 79: 161-165.

4. Vittimberga FJ, Foley DP, Meyers WC, et al. Laparoscopic surgery and the systemic immune response. Ann Surg 1998; 227: 326-334.

5. Watt DG, Horgan PG, McMillan DC. Routine clinical markers of the magnitude of the systemic inflammatory response after elective operation: a systematic review. Surgery 2015; 157: 362-380.

6. Mitaka C. Clinical laboratory differentiation of infectious versus noninfectious systemic inflammatory response syndrome. Clin ChimActa 2005; 35l: 17-29.

7. Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J ClinInvest 2003; 111: 1805- 12.Medline:12813013.

8. Lindberg M, Hole A , Johnsen H , et al. Reference intervals for procalcitonin and C-reactive protein after major abdominal surgery. Scand J Clin Lab Invest 2002; 62: 189-194.

9. Malik E, Schmidt M, Scheidel P. Complications after 106 laparoscopic hysterectomies. Zentralbl Gynakol 1997; 119: 611-615.

10. Marana R, Busacea M, Zupi E, et al. Laparoscopically assismd vaginal hysterectomy versus total abdomincd hysterectomy: a prospective, randomized, multicenter study. Am J Obstet Gynecol 1999; 180: 270-275.

11. Labib M, Palfrey S, Paniagua E, et al. The postoperative inflammatory response to injury following laparoscopic assisted vaginal hysterectomy versus abdominal hysterectomy. Ann Clin Biochem 1997; 34: 543-545.

12. Malik, O. Buchweitz, M. Miiller-Steinhardt, P. et al. Prospective evaluation of the systemic immune response following abdominal, vaginal, and laparoscopically assisted vaginal hysterectomy. Surg Endosc 200l; 15: 463-466.

13. Maruszynski M, Pojda Z. Interleukin-6 (It-6) levels in the monitoring of surgical trauma. Surg Endosc 1994; 8: 1216-1220.

14. Einarsson JI, Matteson KA, Schulkin J, et al. Minimally invasive hysterectomies-a survey on attitudes and barriers among practicing gynecologists. J Minim Invasive Gynecol 2010; 17: 167-175.

15. Ellström M, Bengtsson A, Tylman M, et al. Evaluation of tissue trauma after laparoscopic and abdominal hysterectomy: measurements of neutrophil activation and release of interleukin-6, cortisol, and C-reactive protein. J Am Coll Surg 1996; 182: 423-430.

16. Reisinger KW, Poeze M, Hulsewé KW, et al. Accurate prediction of anastomotic leakage after colorectal surgery using plasma markers for intestinal damage and inflammation. J Am Coll Surg 2014; 219: 744-751.

17. Platt J, Ramanathan M, Crosbie R, et al. Creactive protein as a predictor of postoperative infective complications after curative resection in patients with colorectal cancer. Ann Surg Oncol 2012; 19: 4168-4177.

18. Daams F, Wu Z, Lahaye MJ, et al. Prediction and diagnosis of colorectal anastomotic leakage: a systematic review of literature. World J Gastrointest Surg 2014; 6: 14-26.

19. Mirnezami A, Mirnezami R, Chandrakumaran K, et al. Increased local recurrence and reduced survival from colorectal cancer following anastomotic leak: systematic review and metaanalysis. Ann Surg 2011; 253: 890-899.

20. Mustard RA Jr, Bohnen JMA, Haseeb S, et al. Creactive protein levels predict postoperative septic complications. Arch Surg 1987; 122: 69-73.

21. Ortega-Deba lion R RadaJs F, Facy O, D'Athis R Masson D, Charles PE, et al. C-reactive protein is an early predictor of septic complications after elective colorectal surgery. World J Surg 2010; 34: 808-814.

22. Povoa P, Coelho L, Almeida E, et al. C-reactive protein as a marker of infection in critically ill patients. Clin Microbiol Infect 2005; 11: 101-108.

23. Hunziker S, Hugle T, 5chuchardt K, et al. The value of serum procalcitonin level for differentiation of infectious from noninfectious causes of fever after orthopaedic surgery. J Bone Joint Surg Am 2010; 92: 138-148.

24. Jebali MA, Hausfater P, Abbes Z, et al. Assessment of the accuracy of procalcitonin to diagnose postoperative infection after cardiac surgery. Anesthesiology 2007; 107: 232-238.

25. Tan JS, Lukacz ES, Menefee SA, et al. Determinants of vaginal length. Am J Obstet Gynecol 2006; 195: 1846-1850.

26. Komisaruk BR, Frangos E, Whipple B. Hysterectomy improves sexual response? Addressing a crucial omission in the literature. J Minim Invasive Gynecol 2011; 18: 288-295.