Ayhan KARAKÖSE, Mehmet YÜKSEL, Necip PİRİNÇÇİ, Sacit GÖRGEL, Yusuf ATEŞÇİ, Bilal GÜMÜŞ

The effect of antibiotherapy used against the PSA increase in serum PSA levels

Aim.To evaluatethe effect of antibiotics in patients with PSA value high than 4 ng / ml ontPSA, fPSA and fPSA / tPSA ratio.Methods.A total of96 patients included the study withdetected high level than 4 ng / ml serum PSA. Patients were divided into 2groups according to the high level of PSA value. Group 1 included 49 patients with PSA level between 4-10ng/ml. Group 2 included 47 patients with PSA level high than 10 ng/ml. Patientswere treated with Ciprofloxacin (500mgb.i.d.) orally for 2 weeks. All patients' PSA levels were evaluated and analyzed before and afterantibiotic treatment. Statistical analyses were performed with SPSS version 18.A p value <0.05 was considered significant.Results.The meanage was 61.6 ±5.7 (51-75) years in group 1 and 63.1 ±8.7 (55-74) years in group2. Suspicious DRE findings were significantly high in group 2. The mean tPSA values were6.82±0.42 and 5.93±0.36 before and after antibiotic treatment in group 1respectively. There was no significant differences tPSA value before and afterantibiotic treatment in group 1. Themean tPSA values were 32.53±8.23 and 11.72±5.61 before and after antibiotictreatment in group 2 respectively. The mean tPSA value decreased significantlyafter antibiotic treatment in group 2. Prostate cancer was detected in 32 patients after TRUS guided prostatebiopsy. Prostate cancer was identifiedin 13 patients in gruop 1 and 19 patients in group 2. Conclusıons.Antibiotic treatment in patients with PSA levels high than 10 ng/ml iseffective on prostate biopsy decision and antibiotic treatment can preventunnecessary prostate biopsies.

Keywords:

Prostate, cancer, PSA, biopsy,

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