Mean platelet volume: A simple tool for early risk stra- tification of pulmonary embolism

Pulmonary embolism (PE) is still a major health problem associated with a significant mortality and morbidity. Rapid recognition of massive and submassive cases should be easy and available in order to commencement of appropriate therapy. The aim of this study is to assess the relationship between mean platelet volume (MPV) and PE severity. Three hundred twenty five patients with proven PE (massive=113, submassive =129, and non-massive=83 patients) groups were retrospectively evaluated. The mean age of the participants was 68 years. The distribution of age was different among PE and control cases. The MPV value of patients with PE group was significantly higher compared to healthy subjects 9.8±1.7 fl vs. 9.1±0.8 fl, p<0.001). There were significant differences in regards to MPV levels between the patients with massive, sub-massive, and non-massive PE [10 (6.9-17.2) vs. 9.8 (6.6-19.5) vs. 9.2(5.8-13.2) fl, respectively p = 0.004]. MPV is significantly higher in subjects with newly diagnosed PE patients and also MPV is strongly associated with the severity of PE.

___

1. Goldhaber SZ. Pulmonary embolism. Lancet 2004; 363: 1295-305.

2. Palmieri V, Gallotta G, Rendina D, et al. Troponin I and right ventricular dysfunction for risk assessment in patients with nonmassive pulmonary embolism in the Emergency Department in combination with clinically based risk score. Intern Emerg Med 2008; 3: 131-138.

3. Becattini C, Agnelli G. Acute pulmonary embolism: risk stratification in the emergency department. Intern Emerg Med 2007; 2: 119-129.

4. Masotti L, Righini M, Vuilleumier N, et al. Prognostic stratification of acute pulmonary embolism: focus on clinical aspects, imaging, and biomarkers. Vasc Health Risk Manag 2009; 5: 567- 575.

5. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 2011; 17: 47-58.

6. Rifaioglu EN, Sen BB, Ekiz O. Mean platelet volume and eosinophilia relationship in patients with bullous pemphigoid. Platelets. 2014; 25: 264- 267.

7. Hekimsoy Z, Payzin B, Ornek T, Kandoğan G. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications 2004; 18: 173-176.

8. Arslan E, Yakar T, Yavaşoğlu I. The effect of smoking on mean platelet volume and lipid profile in young male subjects. Anadolu Kardiyol Derg 2008; 8: 422-425.

9. Kostrubiec M, Labyk A, Pedowska-Wloszek J, et al. Mean platelet volume predicts early death in acute pulmonary embolism. Heart 2010; 96: 460- 465.

10. Torbicki A, Perrier A, Konstantinides S, et al. ESC Committee for Practice Guidelines (CPG). Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). Eur Heart J 2008; 29: 2276-2315.

11. Mirzaie AZ, Abolhasani M, Ahmadinejad B, Panahi M. Platelet count and MPV, routinely measured but ignored parameters used in conjunction with the diagnosis of acute coronary syndrome: single study center in Iranian population, 2010. Med J Islam Repub Iran 2012; 26: 17-21.

12. Avramakis G, Papadimitraki E, Papakonstandinou D, et al. Platelets and white blood cell subpopulations among patients with myocardial infarction and unstable angina. Platelets 2007; 18: 16-23.

13. Tsiara S, Elisaf M, Jagroop IA, Mikhailidis DP. Platelets as predictors of vascular risk: is there a practical index of platelet activity? Clin Appl Thromb Hemost 2003; 9: 177-190.

14. Chung T, Connor D, Joseph J, et al. Platelet activation in acute pulmonary embolism. J Thromb Haemost 2007; 5: 918-924.

15. Ermiş H, Yucel N, Gulbas G, Turkkan S, Aytemur ZA. Does the mean platelet volume have any importance in patients with acute pulmonary embolism? Wien Klin Wochenschr 2013; 125: 381- 385.

16. Varol E, Icli A, Uysal BA, Ozaydin M. Platelet indices in patients with acute pulmonary embolism. Scand J Clin Lab Invest 2011; 71: 163-167.

17. Günay E, Sarinc Ulasli S, Kacar E, et al. Can platelet indices predict obstruction level of pulmonary vascular bed in patients with acute pulmonary embolism? Clin Respir J 2014; 8: 33-40.

18. Vagdatli E, Gounari E, Lazaridou E, et al. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010; 14: 28-32.

19. Coutance G, Le Page O, Lo T, Hamon M. Prognostic value of brain natriuretic peptide in acute pulmonary embolism. Crit Care 2008; 12: R109.

20. Binder L, Pieske B, Olschewski M, et al. Nterminal pro-brain natriuretic peptide or troponin testing followed by echocardiography for risk stratification of acute pulmonary embolism. Circulation 2005; 112: 1573-1579.
Eastern Journal of Medicine-Cover
  • ISSN: 1301-0883
  • Başlangıç: 1996
  • Yayıncı: ERBİL KARAMAN
Sayıdaki Diğer Makaleler

Staphylococcal toxic shock syndrome with preexposure to COX-2 inhibitor: Symptom masking and delayed treatment

Min Wei CHİNG, Chee Ping CHONG

Punicalagin isolated from Punica granatum husk can decrease the inflammatory response in RAW 264.7 macrophages

MEHMET BERKÖZ, Oruc ALLAHVERDİYEV

Does HRT change intraocular pressure in postmenopausal women?

SAİT COŞKUN ÖZCAN, Harun Egemen TOLUNAY, DENİZ ÖZARSLAN ÖZCAN, FATİH MEHMET ADIBELLİ

The outcomes of open reduction by the medial approach for developmental dysplasia of the hip in the 3-18 months old patients

Tülin TÜRKÖZÜ, SAVAŞ GÜNER, MEHMET FETHİ CEYLAN, Necip GÜVEN

Histopathological and mechanical properties of different meshes in a rat model of pelvic prolapse surgery

Gülhan Güneş ELÇİ

Epstein-Barr virus positive primary sinonasal nasopharyngeal-type undifferentiated carcinoma: A distinct entity

Ramesh KUMAR3, Salina HUSAİN1, Nik Mohd HUSSİN, Farah Dayana ZAHEDİ1

Does Chiari’s Network affect atrial septal defect measurement?

Fatma Nur GÜMRÜKCÜOĞLU, Hasan Ali GÜMRÜKCÜOĞLU

Mean platelet volume: A simple tool for early risk stra- tification of pulmonary embolism

Ayşegül ŞENTÜRK, ASİYE KANBAY, Serpil ERDOĞAN, Habibe HEZER, HATİCE CANAN HASANOĞLU, Hatice KILIÇ, Tuba ÖĞÜT

Bilateral intraorbital hemorrhage with factor XIII deficiency after strabismus surgery

ERBİL SEVEN, MUHAMMED BATUR, Adnan ÇİNAL, TEKİN YAŞAR, AHMET DEMİROK

Ultrasound practice in emergency medicine

Ali Haydar AKÇA