Salih ÇİBUK, Bayram YURTKULU, Nihat MERT, Handan MERT

Effect of Couch Grass (Agropyrum Repens) on Gentamicin-Induced Nephrotoxicity

Couch grass is used to clean the urinary tract during infections due to its diuretic and antimicrobial effects. The aim of this study was to investigate the possible protective or therapeutic effects of couch grass on gentamycin-induced nephrotoxicity in rats. Four groups of 10 rats were formed in the study. First group, Control: Rats were fed with standard rat feed and water. Second group (couch grass): 3 gr/ L couch grass was added to the drinking water of rats for 7 days. The third group (gentamicin): Gentamicin 80 mg/ kg/ day/ i.p. was given for 7 days. The fourth group (gentamicin + couch grass): Gentamicin 80 mg/ kg/ day/ i.p. and 3 g / L couch grass was added to drinking water for 7 days. One week after the experimental application, blood samples were taken and serum was separated. Albumin, BUN, creatinine, urea, GGT, ALP, Na, Cl and K levels were determined in autoanalyzer. Cystatin C was measured by ELISA. Serum BUN, creatinine, urea, Na, K levels were highest in the gentamicin group. Na, K and cystatin C levels differences between groups were not statistically significant. The increase in BUN, urea and creatinine after gentamicin administration was statistically significant (p

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1. İşlekel H. Böbrek fonksiyonları ve bozuklukları. In, Onat T, Emerk K, Sözmen EY. İnsan Biyokimyası. Türkiye, Palme Yayıncılık. 2002;37-42.
2. David J, Newman MSC, PhD (eds). Tietz basic prenciples in clinical chemistry. Çev Ed. Aslan D. Klinik kimyada temel ilkeler. Türkiye. Palme Yayıncılık. 2005
3. 3.Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P. Acute Dialysis Quality Initiative workgroup. Acute renal failure—definition, outcome measures, animal models, fluid therapy and information technology needs: the second international consensus conference of the Acute Dialysis Quality Initiative Group. Crit Care. 2004; 8:204–12.
4. 4.Guignard JP, Dukker A. Clinical neonatal nephrology. In, Barratt TM, Avner ED, Harmon WE, Eds Pediatric Nephrology (4th ed), Philedelphia: Lipincott Williams and Wilkins. 1999;1051-66.
5. Yurdakök M, Erdem G. Böbrek ve İşlevleri. Türk Neonatoloji Derneği, Neonatoloji:2003.
6. Birol L. İdrar Yolları-Böbrek Hastalıkları Tedavisi ve Hemşirelik Bakımı. İç Hastalıkları ve Hemşirelik Bakımı. Ed: N. Akdemir, L. Birol. Sistem Ofset Basım: Ankara; 2005.
7. Karadeniz G. İç hastalıkları hemşireliğinde teoriden uygulamaya temel yaklaşımlar. Ankara: Baran Ofset. 2008;284-306.
8. Al-Snafi AE. Chemical constituents and pharmacological activities of Ammi majus and Ammi visnaga, A review. Int J P Ind. Res. 2013;3(3),257-65.
9. Marbut M, Ideen and Al-Snafi AE. The probable therapeutic effects of Date palm pollens in treatment of male infertility, Tikrit Journal of Pharmaceutical Sciences. 2005;1(1):30-35.
10. Ozdek U, Seckin H, Cibuk S. Investigation of Antimicrobial Effects of Amygdalus Trichamygdalus (Sweet Almond) and Amygdalus nana L. (Bitter Almond) Plants. Van Vet J. 2020; 31: (1), 22-26.
11. Koçak Y, Oto G, Meydan İ, Şeçkin H. Investigation of Total Flavonoid, DPPH Radical Scavenging, Lipid Peroxidation and Antimicrobial Activity of Allium schoenoprasum L. Plant Growing in Van Region. YYU Journal of Agricultural Science. 2020; 30: (1), 147-155
12. Meydan İ, Kizil G, Demir H, Toptanci BC, Kizil M. In vitro DNA damage, protein oxidation protective activity and antioxidant potentials of almond fruit (Amygdalus trichamygdalus) parts (hull and drupe) using soxhlet ethanol extraction. ADV TRADIT MED (ADTM). 2020; 20: 571–579
13. Özdek U, Yıldırım S and Değer Y. The effect of Diplotaenia turcica root extract in streptozotocin-induced diabetic rats. Turkish Journal of Biochemistry. 2020;42(2)
14. Blake S. Medicinal plants action, Life Long Press:2004.
15. Hautmann C, Scheithe K. Fluid extract of Agropyron repens for the treatment of urinary tract infections or irritable bladder, Results of multicentric post-marketing surveillance, Zeitschrift für Phytotherapie. 2000;21(5):252- 55.
16. Grases F, Ramis M, Costa-Bauza A, March JC. Effect of herniaria hirsute and agropyron repens on calcium oxalate urolithiasis risk in rat, Journal Ethnopharmacology. 1995;45:211- 14.
17. Humes HD. Acute renal failure prevaling challanges and prospects for the future. Kidney Int. 1995;48:26-32.
18. Bennet WM. Aminoglycoside nephrotoxicity. Nephron. 1983;35:73-77.
19. Ataman N, Mert H, Yıldırım S, Mert N. The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 2018; 65.1: 9-14.
20. Ali BH. Gentamicin nephrotoxicity in humans and animals: some recent research. Gen Pharmacol. 1995; 26: 1477-87.
21. Harmon WE. Eds Pediatric Nephrology (4th ed), Philedelphia: Lipincott Williams and Wilkins. 1999;1051-66.
22. Coles EH. Veterinary Clinical Pathology. Fourth Edn. W.B. Saunders Co, Philadelphia:1986
23. Mert N. Veteriner Klinik Biyokimya, U.U. Guclendirme Vakfı Yayın 12 (in Turkish) 1996
24. Pınar N, Karataş Y, Dağlıoğlu YK, Gönlüşen G. Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats. Cukurova Medical Journal.2020; 45.1: 251-256.