Dosimetric Comparison of 3D-Conformal and IMRT Radiotherapy Techniques in Gastric Cancer

Stomach cancer is a malignancy which has poor prognosis and takes place on the top among deaths related with cancer in the world. Anatomically, stomach has relations with critical organs as heart, liver, kidneys, intestine and spinal cord. Doses which are taken by surrounding critical organs in planning adjuvant radiotherapy of stomach cancer have importance in terms of the control and toxicity. In this study, it was aimed to examine the best dose to target volume and the most appropriate treatment planning technique for maximum protection of organs at risk. The Intensity Modulated Radiation Therapy (IMRT) technique and the 3D-Conformal radiotherapy technique at patients who were operated for stomach cancer were compared in terms of dosimetry. This study was done on the Computed Tomography (CT) simulation images of 21 patients who applied to Van Yüzüncü Yıl University, Radiation Oncology Department. CT simulation of patients was taken with 3 mm thickness at 60th second using intravenous contrast agent. Then CT images were transferred to Prowess Panther treatment planning system. In IMRT planning, 5 fields planning were done with 6 MV photon energy. 3D-conformal planning was performed in 4 fields using 6 and 15 MV photon energy. It is seen that IMRT technique is statistically more advantageous against conformal radiotherapy technique in terms of right-left kidney V20, bilateral kidney V20 and mean dose of liver at the radiotherapy technique applied to the patients who had operation for stomach cancer.

___

1. Yao JC, Mansfield PF, Pisters PWT, et al. Combined-Modality Therapy for Gastric cancer. Seminars in surgical Oncology 2003; 21: 223-227.

2. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012; 62: 10-29.

3. Macdonald JS, Smalley SR, Benedetti J, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 2001; 345: 725-730.

4. MacDonald JS, Smalley S, Benedetti J, et al. Postoperative combined radiation and chemotherapy improves disease free survival (DFS) and overall survival (OS) in resected adenocarcinoma of the stomach and gastroesophageal junction: update of the results of Intergroup Study INT-0116 (SWOG 9008). Gastrointestinal Cancers Symposium Program/ Proceedings, American Society of Clinical Oncology 2005; 106.

5. Tepper JE, Gunderson LL. Radiation treatment parameters in the adjuvant postoperative therapy of gastric cancer. Semin Radiat Oncol 2002; 12: 187-195.

6. Marks LB, Yorke ED, Jackson A, Ten Haken RK, Constine LS, Eisbruch A, et al. Use of normal tissue complication probability models in the clinic. Int J Radiat Oncol Biol Phys 2010; 76: 10-19.

7. Matzinger O, Gerber E, Bernstein Z, et al. EORTC-ROG expert opinion: Radiotherapy volume and treatment guidelines for neoadjuvant radiation of adenocarcinomas of the gastroesophageal junction and the stomach. Radiotherapy and Oncology 2009; 92: 164-175.

8. Minn AY, Hsu A, La T, et al. Comparison of intensity modulated radiotherapy and 3 dimensional conformal radiotherapy as adjuvant therapy for gastric cancer. Cancer 2010; 116: 3943-3952.

9. Ringash J, Perkins G, Brierley J, et al. IMRT for adjuvant radiation in gastric cancer: a preferred plan? Int J Radiat Oncol Biol Phys 2005; 63: 732- 738.

10. Wieland P, Dobler B, Mai S, et al. IMRT for postoperative treatment of gastric cancer: covering large target volumes in the upper abdomen: a comparison of a step-and-shoot and an arc therapy approach. Int J Radiat Oncol Biol Phys 2004; 59: 1236-1244.

11. Milano MT, Garofalo MC, Chmura SJ, et al. Intensity-modulated radiation therapy in the treatment of gastric cancer: early clinical outcome and dosimetric comparison with conventional techniques. Br J Radiol 2006; 79: 497-503.

12. Alani S, Soyfer V, Strauss N, et al. Limited advantages of intensity-modulated radiotherapy over 3D conformal radiation therapy in the adjuvant management of gastric cancer. Int J Radiat Oncol Biol Phys 2009; 74: 562-566.
Eastern Journal of Medicine-Cover
  • ISSN: 1301-0883
  • Başlangıç: 1996
  • Yayıncı: ERBİL KARAMAN
Sayıdaki Diğer Makaleler

Factors Influencing the Ethical Sensitivity of Nurses Working in a University Hospital

Esma Ayşe ÖZTÜRK, ASUMAN ŞENER, ZELİHA KOÇ, LATİF DURAN

The Comparison of Diffusion Weighted Imaging (DWI) with Other Breast MRI Parameters in the diagnosis of Breast Masses

Mesut OZGOKCE, Nuri HAVAN, Ferhat CUCE, Fatma DURMAZ, Zakir SAKCI

A Successful Intra-Pleural Fibrinolytic Therapy With Alteplase in A Patient with Empyematous Multiloculated Chylothorax

Mohamed FAİSAL, Rayhan AMİSENO, Nurashikin MOHAMMAD

Prick Test Results and Total IgE Levels of Asthma Patients in A University Hospital

Barış ÇİL, Mehmet KABAK, İCLAL HOCANLI, Ayşe Füsun TOPÇU, MAHŞUK TAYLAN

Ruptured Pulmonary Hydatid Cysts in The Course of Enteric Fever; An Unreported Case

Hanifi YILDIZ, SELAMİ EKİN, AHMET ARISOY, Hatice BEYAZAL POLAT, Fatma BEYAZAL ÇELİKER

Pulmonary Adenocarcinoma Presented With LambertEaton Myasthenic Syndrome

Fettah EREN, Recep AYGÜL, Şerefnur ÖZTÜRK

The Place of Preoperative Imaging Scans In Parathyroid Surgery

Sema YÜKSEKDAĞ, Ahmet TOPÇU, Fatma Gülçiçek AYRANCI, Esin CIBIROĞLU, Ethem ÜNAL

Anesthesia Management in Laparoscopic Sleeve Gastrectomy Cases

ARZU ESEN TEKELİ, Esra EKER, Mehmet Kadir BARTIN, Muzaffer Önder ÖNER

Is Hyaluran A Biomarker In Patients Without SepsisRelated Liver Injury?

İlhan BAHAR, GÜLSEREN ELAY, ADNAN BAYRAM

Methods For The Diagnosis of Acute Appendicitis In Pregnant Women

Tolga KALAYCI, ÜMİT HALUK İLİKLERDEN