Can We Estimate the Recurrence of Primary Spontaneous Pneumothorax With Simple Blood Tests?

Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are associated with in inflammatory diseases and inflammation plays an important role in primary spontaneous pneumothorax (PSP). Therefore, this study evaluated the relationship between estimating recurrence risk and simple blood test such as NLR and PLR in patients with PSP. We designed a retrospective study examining the benefit of NLR and PLR in estimating recurrence in PSP patients. Patients were divided into 3 groups according to their recurrence: Group 1 (132 patients; defined as no recurrence); Group 2 (46 patients; defined as one recurrence); Group 3 (16 patients; defined as two or more recurrence). The clinical blood parameters were compared among the groups. Mann-Whitney U test, Chi-square and ANOVA test were used to analyze data. NLR and PLR were significantly elevated in patients with recurrent PSP (p

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1. Bobbio A, Dechartres A, Bouam S, et al. Epidemiology of spontaneous pneumothorax: Gender-related differences. Thorax 2015; 70: 653-658.

2. Hsu HH, Chen JS. The etiology and therapy of primary spontaneous pneumothoraces. Expert Rev Respir Med 2015; 9: 655-665.

3. Noppen M, Alexander P, Driesen P, Slabbynck H, Verstraeten A. Manual aspiration versus chest tube drainage in first episodes of primary spontaneous pneumothorax: A multicenter, prospective, randomized pilot study. Am J Respir Crit Care Med 2002; 165: 1240-1244.

4. Guo Y, Xie C, Rodriguez RM, Light RW. Factors related to recurrence of spontaneous pneumothorax. Respirology 2005; 10: 378-384.

5. Vuong NL, Elshafay A, Thao LP, et al. Efficacy of treatments in primary spontaneous pneumothorax: A systematic review and network meta-analysis of randomized clinical trials. Respir Med 2018; 137: 152-166.

6. Huang TW, Cheng YL, Tzao C, et al. Factors related to primary bilateral spontaneous pneumothorax. Thorac Cardiovasc Surg 2007; 55: 310-312.

7. Sadikot RT, Greene T, Meadows K, Arnold AG. Recurrence of primary spontaneous pneumothorax. Thorax 1997; 52: 805-809.

8. Chen YW, Chiu WC, Chou SH, et al. High Nrf2 expression in alveolar type I pneumocytes is associated with low recurrences in primary spontaneous pneumothorax. Kaohsiung J Med Sci 2017; 33: 496-502.

9. De Smedt A, Vanderlinden E, Demanet C, et al. Characterisation of pleural inflammation occurring after primary spontaneous pneumothorax. Eur Respir J 2004; 23: 896- 900.

10. Goven D, Boutten A, Malas V, et al. Induction of heme oxygenase-1, biliverdin reductase and h-ferritin in lung macrophage in smokers with primary spontaneous pneumothorax: Role of hif-1α. PLoS One 2010; 5: 5.

11. Erek TA, Ozlu E, Uzuncakmak TK, et al. Neutrophil/Lymphocyte Ratio, Serum Endocan, and Nesfatin-1 Levels in Patients with Psoriasis Vulgaris Undergoing Phototherapy Treatment. Med Sci Monit 2016; 22: 1232-1237.

12. Pan L, Du J, Li T, Liao H. Platelet-tolymphocyte ratio and neutrophil-tolymphocyte ratio associated with disease activity in patients with Takayasu’s arteritis: a case-control study. BMJ Open 2017; 7: 4.

13. Uslu AU, Kücük A, Sahin A, et al. Two new inflammatory markers associated with Disease Activity Score-28 in patients with rheumatoid arthritis: neutrophil-lymphocyte ratio and platelet-lymphocyte ratio. Int J Rheum Dis 2015; 18: 731-735.

14. Hu ZD, Sun Y, Guo J, et al. Red blood cell distribution width and neutrophil/lymphocyte ratio are positively correlated with disease activity in primary Sjögren’s syndrome. Clin Biochem 2014; 47: 287-290.

15. Rifaioglu EN, Bülbül SB, Ekiz O, et al. Neutrophil to lymphocyte ratio in Behçet’s disease as a marker of disease activity. Acta Dermatovenerol Alp Pannonica Adriat 2014; 23: 65-67.

16. Zhang F, Chen Z, Wang P, et al. Combination of platelet count and mean platelet volume predicts postoperative prognosis in both resectable early and advanced stage esophageal squamous cell cancer patients. Tumor Biol 2016; 37: 9323-9331.

17. Akboga MK, Canpolat U, Yuksel M, et al. Platelet to lymphocyte ratio as a novel indicator of inflammation is correlated with the severity of metabolic syndrome: A single center large-scale study. Platelets 2016; 27: 178-183.

18. Akboga MK, Canpolat U, Yuksel M, et al. Association of Platelet to Lymphocyte Ratio With Inflammation and Severity of Coronary Atherosclerosis in Patients With Stable Coronary Artery Disease. Angiology 2016; 67: 89-95.

19. Sahn SA, Heffner JE. Spontaneous pneumothorax. N Engl J Med 2000; 342: 868- 874.

20. Al-Qudah A. Treatment options of spontaneous pneumothorax. Indian J Chest Dis Allied Sci 2006; 48: 191-200.

21. Güneylioglu D, Altınsoy B, Çelik O, Mihmanlı A, Akkaya E. Pneumothorax: Evaluation of 174 cases. Turkiye Klinikleri Arch Lung 2002; 2: 78-81.

22. Walker SP, Bibby AC, Halford P, et al. Recurrence rates in primary spontaneous pneumothorax: a systematic review and metaanalysis. Eur Respir J 2018; 6: 52.

23. Graziosi L, Marino E, De Angelis V, et al. Prognostic value of preoperative neutrophils to lymphocytes ratio in patients resected for gastric cancer. Am J Surg 2015; 209: 333-337.

24. Seretis C, Gourgiotis S, Gemenetzis G, et al. The significance of neutrophil/lymphocyte ratio as a possible marker of underlying papillary microcarcinomas in thyroidal goiters: a pilot study. Am J Surg 2013; 205: 691-696.

25. Wang D, Yang JX, Cao DY, et al. Preoperative neutrophil-lymphocyte and platelet lymphocyte ratios as independent predictors of cervical stromal involvement in surgically treated endometrioid adenocarcinoma. Onco Targets Ther 2013; 6: 211-216.

26. Azab B, Shah N, Akerman M, McGinn JT Jr. Value of platelet/lymphocyte ratio as a predictor of all cause mortality after non-STelevation myocardial infarction. J Thromb Thrombolysis 2012; 34: 326-334.

27. Turkmen K, Erdur FM, Ozcicek F, et al. Platelet to lymphocyte ratio better predicts inflammation than neutrophil to lymphocyte ratio in end stage renal disease patients. Hemodial Int 2013; 17: 391-396.
Eastern Journal of Medicine-Cover
  • ISSN: 1301-0883
  • Başlangıç: 1996
  • Yayıncı: ERBİL KARAMAN
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