Halil KARA, Ayşe Betül ÖZTÜRK, Miray ÇETİNKAYA

Sülprid ile Ereksiyonun Önlenmesi Hipospadias Cerrahisinde Başarıyı Artırmanın Bir Yolu Olabilir mi? Bir Olgu Sunumu

Hipospadias cerrahi olarak tedavi edilmekte ve cerrahide farklı yöntemler kullanılabilmektedir. Ergenlik döneminde ve daha sonra erişkinlikte meydana gelen istem dışı ereksiyonlar nedeniyle yeni oluşturulan üretra yara iyileşmesi tamamlanana kadar risk altındadır. Penis ameliyatı sonrası oluşan ereksiyonlar ağrılıdır ve dikişlerin dayanıklılığını azaltması nedeniyle iyileşme sürecini olumsuz şekilde etkileyebilir. Bu nedenle, özellikle ergenlik döneminde, hipospadias cerrahisinden sonra sertleşmenin önlenmesi ve ağrı yönetimi son derece önemlidir. Ereksiyonun önlenmesi ameliyattan elde edilecek başarı şansını artırabilir. Antipsikotiklerin kısa süreli kullanımı ereksiyonu önlemek için faydalı olabilir. Bu olgu sunumunda on sekiz yaşındaki bir hastada hipospadias onarımı sonrası sülprid kullanımı ve bu tedavinin ameliyatın sonuçlarına olan etkisi sunulmaktadır.

Anahtar Kelimeler:

sülprid, hipospadias, ereksiyon önlenmesi, ergenlik

Can Prevention of Erection with Sulpride be a Way to Increase Success in Hypospadias Surgery? A Case Report

Hypospadias is treated surgically and different methods can useable for this way. Due to involuntary erections during adolescence and later, neourethra seems at risk until wound healing is complete. Erections following penile surgery are painful and can affect the healing process negatively, because the stitches may not withstand a strong erection. Therefore, prevention of erection and management of pain are extremely important after the hypospadias surgery; especially in adolescents. Preventing erection may increase the chance of success from surgery. Short-term use of antipsychotics may be beneficial to prevent erection. In this case report, the use of sulpride in an eighteen-year-old patient after hypospadias repair and the effect of this treatment on the results of the surgery was presented.

Keywords:

sulpride, hypospadias, erection prevention, adolescent,

PDF

___

1. Dolk H, Loane M, Garne E. The prevalence of congenital anomalies in Europe. Adv Exp Med Biol. 2010;686:349-64.
2. Mondaini N, Ponchietti R, Bonafè M, Biscioni S, Di Loro F, Agostini P, et al. Hypospadias: incidence and effects on psychosexual development as evaluated with the Minnesota Multiphasic Personality Inventory Test in a sample of 11 649 Italian men. Urol Int. 2002;68(2):81-5.
3. Moriya K, Kakizaki H, Tanaka H, Furuno T, Higashiyama H, Sano H, et al. Long-term cosmetic and sexual outcome of hypospadias surgery: norm related study in adolescence. J Urol. 2006;176(4 Pt 2):1889-92.
4. Mureau MA, Slijper FM, Nijman RJ, van der Meulen JC, Verhulst FC, Slob AK. Psychosexual adjustment of children and adolescents after different types of hypospadias surgery: a norm-related study. J Urol. 1995;154(5):1902-7.
5. Mitchell R, Smith G. The control of acute postoperative pain. Br J Anaesth. 1989;63(2):147-58.
6. Xie H, Xu YM, Xu XL, Sa YL, Wu DL, Zhang XC. Evaluation of erectile function after urethral reconstruction: a prospective study. Asian J Androl. 2009;11(2):209-14.
7. Carlton J, Patel M, Morey AF. Erectile function after urethral reconstruction. Asian J Androl. 2008;10(1):75-8.
8. Bracka A. Hypospadias repair: the two‐stage alternative. Br J Urol. 1995;76(Suppl 3):31-41.
9. Springer A. Assessment of outcome in hypospadias surgery - a review. Front Pediatr. 2014;2:2.
10. Örtqvist L, Fossum M, Andersson M, Nordenström A, Frisén L, Holmdahl G, et al. Sexuality and fertility in men with hypospadias; improved outcome. Andrology. 2017;5(2):286-93.
11. Mallis D, Moisidis K, Kirana PS, Papaharitou S, Simos G, Hatzichristou D. Moderate and severe erectile dysfunction equally affects life satisfaction. J Sex Med. 2006;3(3):442-9.
12. Khanna A, Saxena R, Dutta A, Ganguly N, Sood J. Comparison of ropivacaine with and without fentanyl vs bupivacaine with fentanyl for postoperative epidural analgesia in bilateral total knee replacement surgery. J Clin Anesth. 2017;37:7-13.
13. Kundra P, Yuvaraj K, Agrawal K, Krishnappa S, Kumar LT. Surgical outcome in children undergoing hypospadias repair under caudal epidural vs penile block. Pediatr Anaesth. 2012;22(7):707-12.
14. Kaplan HS. The new sex therapy: Active treatment of sexual dysfunctions. New York: Brunner/Mazel Publishers; 1974.
15. Stahl SM. Stahl's essential psychopharmacology: neuroscientific basis and practical applications. Cambridge: Cambridge University Press; 2013.
16. Montejo-González AL, Llorca G, Izquierdo JA, Ledesma A, Bousoño M, Calcedo A, et al. SSRIinduced sexual dysfunction: fluoxetine, paroxetine, sertraline, and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients. J Sex Marital Ther. 1997;23(3):176-94.
17.Corona G, Ricca V, Bandini E, Mannucci E, Lotti F, Boddi V, et al. Selective serotonin reuptake inhibitorinduced sexual dysfunction. J Sex Med. 2009;6(5):1259-69.
18. Kennedy SH, Fulton KA, Bagby RM, Greene AL, Cohen NL, Rafi-Tari S. Sexual function during bupropion or paroxetine treatment of major depressive disorder. Can J Psychiatry. 2006;51(4):234-42.
19. Mir S, Taylor D. Sexual adverse effects with new antidepressants. Psychiatr Bull. 2018;22(7):438-41.
20. Kafkaslı A, Cangüven Ö. Effects of antidepressants on sexual functions. Androl Bul. 2013;15(52):1-6.
21. Serretti A, Chiesa A. Treatment-emergent sexual dysfunction related to antidepressants: a meta-analysis. J Clin Psychopharmacol. 2009;29(3):259-66.
22.Bonnot O. Sertraline. Priapism: case report. React Wkly. 2007;1159:26.
23.Cutler A. Sexual dysfunction and antipsychotic treatment. Psychoneuroendocrinology. 2003;28(Suppl 1):69-82.
24. Yelboğa Z, Korgalı E. Psychopharmacology and sexual function. Androl Bul. 2015;17(62):189-93.
25. Penaskovic KM, Haq F, Raza S. Priapism during treatment with olanzapine, quetiapine, and risperidone in a patient with schizophrenia: a case report. Prim Care Companion J Clin Psychiatry. 2010;12(5):PCC.09l00939.
26.Behere PB, Das A, Behere AP. Antipsychotics. In: Clinical psychopharmacology. Singapore: Springer; 2019. p.39-87.
27. Dossenbach M, Dyachkova Y, Pirildar S, Anders M, Khalil A, Araszkiewicz A, et al. Effects of atypical and typical antipsychotic treatments on sexual function in patients with schizophrenia: 12-month results from the Intercontinental Schizophrenia Outpatient Health Outcomes (IC-SOHO) study. Eur Psychiatry. 2006;21(4):251-8.
28. Perrault G, Depoortere R, Morel E, Sanger DJ, Scatton B. Psychopharmacological profile of amisulpride: an antipsychotic drug with presynaptic D2/D3 dopamine receptor antagonist activity and limbic selectivity. J Pharmacol Exp Ther. 1997;280(1):73-82.