Melih Engin ERKAN, Ayşe YILMAZ, Taner UÇGUN, Ayşe Nurdan KORKMAZ, Mehmet Zeki YILMAZTEKİN, Mustafa YILDIRIM, Ahmet Semih DOĞAN, Muhammet AŞIK

İNSÜLİN DİRENCİ İLE GATED MYOKARD PERFÜZYON SPECT SİNTİGRAFİSİNDEN ELDE EDİLEN PARAMETRELERİN İLİŞKİSİ

Amaç: GATED SPECT miyokart perfüzyon sintigrafisi (MPS) çalışmasında elde ettiğimizkardiyovasküler risk parametreleri ile insülin direnci arasındaki ilişkiyi araştırmaktır.Yöntem: Ekim/2011-Nisan/2012 tarihleri arasında koroner arter hastalığı (KAH) öntanısı ileMPS için bölümümüze başvuran diyabet tanısı olmayan 153 hasta çalışmaya dahil edildi.80kadın, 73 erkek (ortalama yaş 54±12) çalışma grubunu oluşturdu. Hastalardan açlık kan örneklerialınıp alınan kan örneklerinde açlık insülin ve açlık kan şekeri seviyeleri ölçüldü. İnsülin direnciHOMA-IR metodu ile hesaplandı. Görsel olarak iskemi varlığı değerlendirildi. Sol ventriküleait sayısal parametreler kantitatif GATED SPECT (QGS) yazılımı ile otomatik olarak elde edildi.Bulgular: Hastalar sintigrafik sonuçlarına göre 90 (%58.8)’ı normal ve 48 (31.3)’i iskemikolarak bulundu. Hastaların insülin değerleri normal grupta 9.06±13.95 ve iskemik grupta7.50±5.71 bulundu (p=0.943). Ayrıca normal grupta HOMA-IR 2.19±3.59 iken iskemik grupta1.71±1.34 olarak bulundu (p=0.368).Sonuç: Çalışmamızda GATED SPECT MPS çalışmasından elde ettiğimiz kardiyovasküler riskparametreleri ile insülin rezistansı arasında anlamlı bir ilişkisinin olmadığı bulunmuştur

Anahtar Kelimeler:

İnsülin direnci, HOMA-IR, Miyokard perfüzyon sintigrafisi

The Relationship Between Insulin Resistance and the Parameters Obtained From Gated Spect Myocardial Perfusion Scintigraphy

Purpose: To investigate the correlation between myocardial perfusion scintigraphic findingsand insulin resistance.Methods: Our study group consisted of 153 non-diabetic patients (80 women and 73 men, meanage 54 ± 12), referred to our department for the myocardial perfusion scintigraphy withsuspected coronary artery disease between October/2011-April/2012., Fasting insulin and bloodsugar levels were measured. Insulin resistance was calculated using HOMA-IR method. Leftventricular quantitative parameters were automatically calculated using quantitative GATEDSPECT (QGS) software.Results: According to the scintigraphic results, 90 (58.8%) of the patients were normal and 48(31.3%) of the patients had ischemia. Mean insulin values of patients were found to be9.06±13.95 in normal group and 7.50±5.71 in the ischemic group (p=0.943). Additionally,HOMA-IR was 2.19±3.59 in normal group and 1.71±1.34 in the ischemic group (p=0.368).There was no significant difference between scintigraphic findings and insulin resistance orHOMA-IR results. Conclusion: We found no significant correlation between insulin resistance and cardiovascularrisk parameters obtained from GATED SPECT MPS

Keywords:

Insulin resistance, HOMA-IR, Myocardial Perfusion Scintigraphy,

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