Kadriye ERDOĞAN, Nazlı Tunca ŞANLIER, Huri GÜVEY, Serdar DİLBAZ, İnci KAHYAOĞLU, Yaprak USTUN

Anti-Mülleryan Hormonun İn Vitro Fertilizasyon Siklus Sonuçlarına Etkisinin Araştırılması

Amaç: Bu çalışma, serum anti-Mülleryan hormon (AMH) seviyesinin in vitro fertilizasyon (IVF) siklus sonuçları üzerindeki etkisini araştırmak için yürütülmüştür. Gereç ve Yöntemler: Bu çalışmaya dahil edilen toplam 142 hasta, serum AMH düzeylerine göre, Grup 1: AMH düzeyi 5-10 ng/mL (n=108), Grup 2: AMH düzeyi 10-15 ng/mL (n=20) ve Grup 3: AMH düzeyi >15 ng/mL (n=14) olmak üzere üç gruba ayrıldı. Demografik özellikler kaydedildi. İnfertilite ve stimülasyon süresi, siklus sayısı, gonadotropinlerin başlangıç, son ve toplam dozları ile tetikleme, oosit toplama (oocyte pick up, OPU) ve embriyo transferi (ET) gününde östradiol (E2) ve progesteron düzeyleri, toplanan toplam oosit sayısı, matur oosit sayısı, embriyo sayısı ve kalitesi ve ayrıca tetikleme, OPU ve ET gününde endometrial kalınlık, embriyo-fundus mesafesi, ET günü ve gebelik sonuçlarının tamamı kaydedildi. Bulgular: IVF tedavi endikasyonları ve gebelik sonuçları gruplar arasında benzer iken, vücut kitle indeksi (VKİ) Grup 2 ve Grup 3'te Grup 1'e göre anlamlı olarak daha yüksekti (p<0,001). Toplam gonadotropin dozları Grup 2'de Grup 1 ve Grup 3’e göre anlamlı olarak daha yüksek ve toplam oosit sayısı da Grup 3'te Grup 1'e göre anlamlı olarak daha yüksek idi (sırasıyla, p=0,006 ve p=0,015). Sonuç: AMH seviyesi VKİ ve toplam oosit sayısı ile ilişkilidir, fakat matur oosit sayısı, oosit kalitesi ve gebelik sonuçları ile ilişkili değildir.

Anahtar Kelimeler:

AMH seviyeleri, IVF siklus sonuçları, VKİ, oosit sayısı ve kalitesi, gebelik sonuçları

Evaluation of Anti-Mullerian Hormone in Predicting In Vitro Fertilization Cycle Outcomes

Aim: This study was conducted to explore the effect of serum anti-Mullerian hormone (AMH) level on in vitro fertilization (IVF) cycle outcomes. Material and Methods: A total of 142 patients included in this study, were divided into three groups according to their serum AMH levels as Group 1: AMH level 5-10 ng/ml (n=108), Group 2: AMH level 10-15 ng/ml (n=20), and Group 3: AMH level >15 ng/ml (n=14). Demographic characteristics were recorded. The duration of infertility and stimulation, the number of cycles, initial, final, and total doses of gonadotropins, and estradiol (E2) and progesterone levels on the day of trigger, oocyte pick up (OPU) and embryo transfer (ET), the total number of oocytes retrieved, the number of mature oocytes, the number and quality of the embryo, and also endometrial thickness on the day of trigger, OPU and ET, the distance of embryo-fundus, the day of ET, and pregnancy outcomes were all recorded. Results: While the IVF treatment indications and pregnancy outcomes were similar between the groups, body mass index (BMI) was significantly higher in Group 2 and Group 3 than in Group 1 (p<0.001). The total doses of gonadotropin were significantly higher in Group 2 than in Group 1 and Group 3, and the total oocyte count was also significantly higher in Group 3 than in Group 1 (p=0.006, and p=0.015, respectively) Conclusion: AMH levels were associated with BMI and total oocyte count, but not with mature oocyte count, oocyte quality, and pregnancy outcomes.

Keywords:

AMH levels, IVF cycle outcomes, BMI, oocyte count and quality, pregnancy outcomes,

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