Tianeptine Addiction: A Case Report

Antidepresan kullanımıyla ilgili olarak, genellikle rastlanan klinik problemler, hastanın ilacı söylenenden daha düşük dozda alması ve istenilenden daha erken tedaviyi sonlandırmasıdır. Antidepresanlarla çekilme belirtilerinin olması uzun zamandır bilinen bir bilgidir fakat tolerans ve kompulsif ilaç kullanımı gibi bağımlılığın diğer özellikleri oldukça nadirdir. Tianeptinin nörobiyolojik özellikleri, birçok nörotransmitter sisteminin dinamik etkileşimini içermektedir. Glutamaterjik sistem üzerine etkilerinin, bu molekülün tetiklediği olaylar zincirinde ve antidepresan etkinliğinde anahtar role sahip olduğu düşünülmektedir. Bu makalede de, "tianeptin bağımlılığı" tanısı konmuş olan bir vaka üstünden tianeptinin kötüye kullanılma potansiyeli özellikle glutamaterjik sistem üzerine olan etkileri üstünde durularak açıklanmaya çalışılmıştır

Tianeptin bağımlılığı: Bir olgu sunumu

Common clinical problems associated with antidepressant therapy, are usage of a lower dose than recommended and cessation of the drug prematurely by the patients themselves. Withdrawal symptoms have been known for a long time, but other features of addiction, such as tolerance and compulsive drug use are very rare. The neurobiological properties of tianeptine involve a dynamic interplay between numerous neurotransmitter systems. The effects of tianeptine on the glutamatergic system can provide a key action in the cascade of events triggered by this compound and its antidepressant efficacy. In this article, with particular emphasis on the effects of tianeptine on the glutamatergic system, the abuse potential of the drug was explained through a case with “Tianeptine addiction” diagnosis

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