Akut Pankreatit Etyolojisinin ve Prognozunun Değerlendirilmesi : 10 yıllık Sonuçlarımız-Retrospektif Çalışma

Amaç Kliniğimizde tedavi edilen akut pankreatitli hastaların etyoloji ve klinik sonuçları açısından değerlendirmeyi amaçladık. Materyal ve Metod Çalışmada 395 AP’li hasta mevcuttu. AP’li hastalar revize Atlanta sınıflamasına göre MAP, MSP ve SAP olarak gruplandı. Tüm hastaların etyolojisi, demografik verileri, hastanede ve yoğun bakımda yatış süresileri kaydedildi. Vücut kitle indeksi(BMI), tanı anındaki amilaz, lipaz, hematokrit, C-reaktif protein(CRP), prokalsitonin, karaciğer fonksiyon testleri, arteryel kan gazı analizleri yapıldı. Sistemik İnflamatuar Cevap Bulguları(SIRS), modifiye Marshall skorlama(MMS) sistemine göre solunumsal, kardiyovasküler ve nefrolojik açıdan organ yetmezlikleri değerlendirildi. CT severity Index’e (CTSI) göre nekroz derecesi tespit edildi. Klinik olarak İmrie skoruna göre pankreatit şiddeti belirlendi. Bulgular Toplamda 395 hasta vardı. Hastaların % 55,6’sı (n:220) erkek, %44,4’ü (n:175) kadındı.Ortalama yaş 54,2 (18-84) idi. AP’nin nedenleri arasında en fazla biliyer pankreatit görüldü. 2. Sıklıkta hipertrigliseridemi görüldü. Tüm hastalar içerisinde %4,05’lik mortalite oranı vardı. Sonuç Sonuç olarak AP’ de en sık etyolojik faktör safra taşlarıdır. Yağlı gıdalarla beslenme alışkanlıklarının artması hipertrigliseridemik AP’yi artırmaktadır.

Anahtar Kelimeler:

akut pankreatit, safra taşı, hipertrigliseridemi, etyoloji

Evaluation of Acute Pancreatitis etiology and prognosis: Our results of ten years-Retrospective study

Introduction Our objective was to evaluate the etiology and clinical results of acute pancreatitis patients treated in our clinic. Material and Method 395 AP patients were included in the study. AP patients were grouped as MAP, MSP and SAP according to the revised Atlanta classification. Etiology, demographic data hospital and intensive care unit hospitalization were recorded for all patients. Body mass index (BMI), amylase, lipase, hematocrit, C-reactive protein (CRP), procalcitonin, liver function tests and arterial blood gas analyses were made during diagnosis. Systemic Inflammatory Response Findings (SIRS) were evaluated in respiratory, cardiovascular and nephrological terms according to modified Marshall scoring (MMS) system. Necrosis degree was detected based on CT Severity Index (CTSI). Pancreatitis severity was clinically determined based on Imrie score. Results There were 395 patients in total. 55.6 of the patients were male (n:220) and 44.4% (n:175) were female. The average age was 54.2 (18-84). Biliary pancreatitis was observed most commonly among AP causes. Hypertriglyceridemia was the second most common cause. Its mortality rate among all patients was 4.05%. Conclusion As a result, gallstones constitute the most common etiological factor in AP. Increasing of nutrition habits with fatty foods increase hypertriglyceridemic AP.

Keywords:

acute pancreatitis, gall stone, hypertriglyceridemia, etiology,

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