FUNDA GÖDE, Erbil DOĞAN, Bahadır SAATLİ, Cemal POSACI

Postmenopozal hastalarda hormon tedavisi ve diğer antirezorbtif ajanların kullanım yaygınlığı ve etkilerinin karşılaştırılması

Amaç: Bu çalışmada amaç kliniğimize başvuran menopoz hastalarının hormon tedavisi ve diğer antirezorbtif ajanları kullanım yaygınlığını araştırmaktır. Ayrıca hastaların kemik mineral yoğunlukları ve mamografi bulguları da değerlendirilmiştir. Gereç ve yöntem: Bu çalışma, Şubat-Aralık 2005 tarihleri arasında başvuran menopoz hastalarının dosyaları taranarak yapılan retrospektif bir araştırmadır. Hastaların demografik özellikleri, kemik mineral yoğunluğu ve dansiteleri, aldıkları tedaviler ve mamografileri incelenmiştir. İstatistiksel analizde t-test, tek yön ANOVA ve çift değişken korelasyon analizi kullanılmıştır (p0,05). Hormon tedavisi alanlar ve almayanlar arasında mamografik bulgular açısından anlamlı fark saptanmadı (p>0,05). Sonuç: Kliniğimizde hormon tedavisi tercih edilen hasta grubunun büyük bir kısmını osteoporozu olmayan hastalar oluşturmaktadır. Osteoporozu olanlarda ise hormon tedavisi veya diğer antirezorbtifler hastanın kliniğine göre benzer oranda tercih edilmektedir. Hormon tedavisi almış olmanın mamografik bulgulara etkisi saptanmamıştır.

Comparison of the effects and utilization incidence of hormonal treatment and other antiresorptive agents in postmennopausal patients

Objective: The aim of the study is to investigate the utilization incidence of hormonal therapy and other antiresorbtive agents in postmenopausal patients appealed to our clinics. Bone mineral density and mammographic findings were also evaluated. Material and method: This study is a retrospective analysis of records of patients who were admitted to menopause outpatient clinic during February-December 2005. Demographic features, bone mineral densitometers, mammographies and prescribed medications were evaluated. One-way ANOVA, t-test, bivariate correlation analysis were used for statistical analysis (p<0.05 was accepted as statistically significant). Results: Osteoporosis was detected in 61 (%18.3) of total 334 patients. 17 (%27.8) of these patients were taking only hormonal therapy, 15 (%24.5) of them were taking other antiresorbtive agents, 10 (%16.3) both and 19(%31.1) none of them. 135(%40) of patients were receiving hormone treatment. Osteoporosis was not detected in 108(%80) of these patients. There was not any statistically significant bone mineral density differences (L1-L4 and femoral t-scores) between the groups of hormonal therapy and other antiresorbtive agents (p>0.05). Hormone therapy, does not seem to affect the mammographic findings (p>0.005). Conclusion: In our clinic, osteoporosis was not determined in most of the patients in hormonal treatment group. Hormonal treatment or other antirezorbtive agents were preferred similarly according to clinical findings in osteoporotic group. It was not detected any effect of hormonal treatment on mammographic findings.

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