Çocuklarda santral sinir sistemi vaskülitleri

Çocukluk çağında Santral Sinir Sistemi (SSS) vaskülitleri, SSS’de izole primer bir hastalık olabileceği gibi altta yatan sistemik hastalıklara sekonder olarak da ortaya çıkabilmektedir. Çocukluk çağı SSS vaskülitleri yakın zamanda tanımlanmış olup ciddi morbidite ve mortaliteye yol açabilmektedir. Primer SSS vaskülitlerinin iki tipi vardır. Bunlar orta ve büyük çaplı damarların tutulduğu anjiografi pozitif tip ve küçük damar tutulumunun olduğu anjiografi negatif tiptir. Birçok enfeksiyon ve sistemik enflamatuvar veya otoimmün hastalık sekonder SSS vaskülitine yol açabilmektedir. Primer ve sekonder SSS vaskülitlerinin klinik, radyolojik, prognoz ve tedavi yaklaşımları farklılık göstermektedir. SSS vasküliti olan çocuklarda erken tanı ve etkili tedavi ile morbidite ve mortalite önlenebilir.

Central nervous system vasculitis in children

Central Nervous System (CNS) vasculitis of childhood can occur as a primary disease limited to the CNS or as a secondary manifestation of an underlying systemic disorder. Central nervous system vasculitis in children is a newly recognized disease and can cause severe morbitidy and mortality. Two different subtypes of primary CNS vasculitis are defined: angiography-positive primary CNS vasculitis affecting large and medium-sized vessels, and angiography-negative primary CNS vasculitis affecting small-sized vessels. Many infections and systemic inflammatory or autoimmune diseases can cause secondary CNS vasculitis. Primary and secondary CNS vasculitis of childhood differ in clinical presentation, radiographic findings, prognosis, and treatment. Early recognition and effective treatment may prevent morbidity and mortality of childhood CNS vasculitis.

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