Non-alkolik yağlı karaciğer hastalığı ve B12 ilişkisi
Amaç: Çağımızda yaşam tarzı düzensizliklerinin bir sonucu olarak çeşitli klinik bozukluklar ortaya çıkmaktadır. Non-alkolik yağlı karaciğer hastalığı (NAYKH) bu klinik bozukluklar arasında adından sıkça söz ettirmektedir. Çalışmanın amacı, NAYKH tanısı konulan hastalarda B12 vitamin değerlerini incelemektir.
Anahtar Kelimeler:
Non-alkolik, yağlı karaciğer, grade, b12 vitamini
The Relationship Between Non-alcoholic Fatty Liver Disease and B12
Objective: In our age, various clinical disorders have emerged as a result of lifestyle disorders. Nonalcoholic fatty liver disease (NAFLD) is frequently mentioned among these clinical disorders. The aim of this study to investigate vitamin B12 levels in patients with NAFLD.Methods: The study was performed retrospectively. The data of the patients diagnosed with NAFLD were obtained through the hospital information management system (HIS). In this study, all patients who met the inclusion criteria were grouped. While 227 of these patients were male, 454 were female. The diagnoses of the patients were made by radiologists based on ultrasonographic (USG) imaging results. Patients without NAFLD were diagnosed as “Grade 0”. Groups were formed for patients diagnosed with NAFLD. Groups; “light Grade I”, “medium Grade II” and “advanced Grade III” was in shape. B12 vitamin values of all patients were determined according to the groups. B12 test parameter was studied in Sakarya University Training and Research Hospital (SÜEAH) biochemistry laboratory and Archıtect i2000 device. Statistical studies were performed using IBM SPSS for Windows Version 20.0 software. Descriptive statistics were calculated in the statistical evaluation of the data. One-way analysis of variance, mann- Whitney U, chi-square and student t test were used to determine the difference between the groups. Statistical significance level was accepted as p<0.05.Results: In this study, B12 values of 681 patients who met our criteria were examined through HIS (Hospital Information Management System). B12 values of male patients were found to be 325.6±190.12 (pq/mL). The B12 value in female patients was found to be 328.13±186.92 (pq/mL). When the liver fat and B12 values were analyzed together, the highest B12 value was found in Grade 0 (299 pq/mL) and the lowest B12 value was found in Grade III (199 pq/mL). This was found to be statistically significant (p<0.05).Conclusion: There is a relationship between NAFLD levels and vitamin B12. According to our opinion; lifestyle research, including eating habits, will reveal this relationship more clearly.
Keywords:
Non-alcolic, fatty liver, grade, vitamine b12,
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- ISSN: 2757-7880
- Yayın Aralığı: Yılda 2 Sayı
- Başlangıç: 2019
- Yayıncı: Hayrullah YAZAR