NURCAN KILIÇ BAYGUTALP, FATİH BAYGUTALP, Buminhan ŞEFEROĞLU, EBUBEKİR BAKAN

The relation between serum vitamin D levels and clinical findings of fibromyalgia syndrome

Amaç: Bu çalışma, fibromiyalji sendromlu (FMS) hastalarda serum 25-OH vitamin D seviyelerini belirlemek ve 25-OH vitamin D seviyelerinin klinik bulgular ile ilişkisini araştırmak amacıyla yapıldı. Yöntemler: Çalışmaya ACR 1990 fibromiyalji tanı kriterlerine göre tanı konulan ondokuz premenapozal kadın ve kontrol grubu olarak 24 premenapozal sağlıklı kadın dahil edildi. Yaygın vücut ağrısı, baş ağrısı, yorgunluk, sabah tutukluğu, uyku bozukluğu, hassas nokta sayısı, fibromiyalji etki anketi skorları ve Beck depresyon skorları FMSnin klinik bulguları olarak değerlendirildi. Bulgular: Serum 25-OH vitamin D seviyeleri FMSli hastalarda kontrol grubuna göre anlamlı olarak daha düşüktü (p=0.01). FMS grubunda 25-OH vitamin D seviyeleri ile yaygın vücut ağrısı (r=-0.731), Beck depresyon skorları (r=-0.777), baş ağrısı (r=-0.629) ve uyku bozukluğu arasında (r=-0.767) anlamlı negatif korelasyonlar vardı (p

Serum vitamin D seviyelerinin fibromiyalji sendromunun klinik bulguları ile ilişkisi

Objective: This study was performed to identify serum 25-OH vitamin D levels and to investigate the relationship between 25-OH vitamin D and clinical findings on patients with fibromyalgia syndrome (FMS). Methods: Nineteen premenopausal women with FMS who were diagnosed according to ACR 1990 fibromyalgia diagnostic criteria and 24 premenopausal healthy women as control group were included in the study. Serum 25-OH vitamin D levels were determined in both patient and control groups. Widespread body pain, headache, fatigue, morning stiffness, sleep disorder, the number of tender points, Fibromyalgia Impact Questionnaire (FIQ) scores and Beck depression scores were evaluated as clinical findings in patients with FMS. Results: Serum 25-OH vitamin D levels were significantly lower in patients with FMS than those in control group (p=0.01). There were significantly negative correlations between 25-OH vitamin D levels and widespread body pain (r=-0.731), Beck depression scores (r=-0.777), headache (r=-0.629), and sleep disorder (r=-0.767) in the FMS group (p<0.01). Conclusion: It was concluded that 25-OH vitamin D deficiency may be related to the clinical findings such as widespread body pain, depression, headache and sleep disorder in patients with FMS.

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