Abdullah SAKİN, Mesut AYER, Kenan ÇELİK, Fatih BERKİL, Hürtan ACAR, Aylin AYER, Ayşegül SAKİN, Fuat ŞAR

The frequency of polyneuropathy and comparison of laboratory parameters in patients with multiple myeloma

Objective: Multiple myeloma(MM) is a B-cell neoplasia, characterized by clonal expansion of malignant plasma cells in bone marrow. Polyneuropathy (PN) is the most important complications in the treatment of MM. The aim of our study is to find out whether the lab parameters and the incidence of PN, are markers in MM patients or not.Methods: Totally 70 patients (31 male, 39 female) who presented to hematology outpatient department were retrospectively evaluated. Pre-treatment laboratory parameters and electromyography records of the patients taken from the file.Results: 15.7% of the cases the diagnosis was immediately available PN. Levels of β2 microglubin, uric acid, total protein, calcium, ALT, AST, creatinine, LDH and albumin levels didn’t differ significantly between two groups (p>0.05).Conclusion: Presence or development of PN in MM and its readiness to be used as an early marker, will obviously facilitate the treatment and follow-up of MM.Key words: Multiple myeloma, polyneuropathy, electromyography

Anahtar Kelimeler:

Multipl miyelom, polinöropati, elektromiyografi

The comparison of Brucella gel agglutination test with other Brucella tests

Objective: In this study, it was aimed to compare the sensitivity of diagnostic tests in patients with a preliminary diagnosis of brucellosis.Methods: We have compared the serological methods, standard tube agglutination test (STA), Coombs Test (CT), Rose Bengal (RBT), and the gel centrifugation test. In patients with a preliminary diagnosis of brucellosis, subjects with a positive test result of RBT has been included in the research and other diagnostic tests STA, CT and Coombs Gel centrifugation tests were performed within the range of same titration.Results: Total 132 patient’s serums were studied. In RBT positive 92 patients’ serums, negative test results were found in 11 with STA, in 9 with CT and in 6 with gel test. While 35 patients were identified to be positive by using Brucella gel test at 1/5120 titer, no positive test results were seen with STA and CT at the same titer. Generally, CT results were one titration below the gel centrifugation test results.Conclusion: In conclusion, RBT and STA were not always adequate to determine the diagnosis of brucellosis. Low titer STA results should be supported by tests such as CT or gel centrifugation and the seroconversion must be monitored. Due to giving fast results, gel centrifugation test can be preferred in diagnosis of Brucellosis.Key words: Brucellosis, gel centrifugation, Coombs test

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Decaux O, Laurat E, Perlat A, et al. Systemic manifestations of monoclonal gammopathy. Eur J Intern Med 2009;20:457-461.
Ramchandren S, Lewis RA. Monoclonal gammopathy and
neuropathy. Curr Opin Neurol 2009;22:480-485.
Richardson PG, Delforge M, Beksac M, et al. Management of treatment-emergent peripheral neuropathy in multiple myeloma. Leukemia 2012;26:595-608.
Holland J, Trenkner DA, Wasserman TH, Fineberg B. Plasmacytoma. Treatment results and conversion to myeloma.
Cancer 1992;69:1513-1517.
Jemal A, Murray T, Samuels A, et al. Cancer Statistics. CA
Cancer J Clin 2003;53:5-26.
Antoine JC, Camdessanché JP. Peripheral nervous system
involvement in patients with cancer. Lancet Neurol 2007;6:75-86.
Denier C, Lozeron P, Adams D, et al. Multifocal neuropathy due to plasma cell infiltration of peripheral nerves in multiple myeloma. Neurology. 2006;66:917-918.
A. Sakin ve ark. Multipl myelomlu hastalarda polinöropati sıklığı
Dicle Tıp Derg / Dicle Med J www.diclemedj.org Cilt / Vol 42, No 4, 445-448
Nobile-Orazio E. Neuropathy and monoclonal gammopathy.
Handb Clin Neurol 2013;115:443-459.
Silberman J, Lonial S. Review of peripheral neuropathy in plasma cell disorders. Hematol Oncol 2008;26:55-65.
Kelly JJ, Kyle RA, O’Brien PC, Kohn J. Prevalence of monoclonal proteins in peripheral neuropathy. Neurology 1981; 31: 1480-1483.
Reddy GK, Mughal TI, Lonial S. Optimizing the management
of treatment-related peripheral neuropathy in patients with multiple myeloma. Support Cancer Ther 2006;4:19-22.
Ramchandren S, Lewis RA. Monoclonal gammopathy and
neuropathy. Curr Opin Neurol 2009;22:480-485.