Terapötik Plazmaferez ve Çift Filtreli Plazmaferez Tedavisinin Karşılaştırılması- Beş Yıllık Nefroloji Merkez Deneyimi
Giriş: Bu çalışmanın amacı, tek merkezde yapılan terapötik plazma değişimi ve çift filtreli plazmaferez tedavisininsonuçlarının ve özelliklerinin değerlendirilmesidir. Yöntemler: 2007-2012 yılları arasında üniversite hastanesinde terapötik plazmaferez ile tedavi edilen olguların verilerigeriye dönük olarak incelendi. 445 TPE ve 391 DFPP seansı yapıldı Bulgular: 5.5 yılda 116 vakada 445 seans TPE ve 391 seans DFPP yapıldı. Ortalama yaş 46.61±16.83yıldı. 49 kadın ve 67erkek hasta vardı. Guillain-Barre sendromu (%8.6) nörolojik hastalıkların en sık rastlanan nedeni iken, böbrekle ilgilihastalıklarda en sık neden glomerülonefritlerdi (%26.1). Dermatolojik hastalıkların nedenleri Diyabetes Mellitus(%13.8) ve Pemfigus Vulgarisdi (%5,2). DFPP ve TPE komplikasyon oranları arasında fark yoktu (p= 0.411). Sonuç: TPE ve DFPP, çok çeşitli hastalıkların tedavisi olarak kullanılan güvenli ve hayati önemi olan tedavi yöntemleridir.Bu tedaviler hemodiyaliz üniteleri yoğun bakım ünitelerinde güvenle yapılabilir ve tedaviye dirençli nörolojikhastalıklarda ilk seçenek olarak DFPP kullanılabilinir.
Comparison of Therapeutic Plasma Exchange and Double FiltrationPlasmapheresis: Five Year Experience of Nephrology Unit
Objective: The aim of the study was to evaluate the outcomes and characteristics of therapeutic plasma exchange (TPE) and double filtration plasmapheresis (DFPP) in one center. Method: The data of cases treated with therapeutic plasmapheresis at the university hospital between 2007 and 2012 were retrospectively analyzed. 445 TPE and 391 DFPP sessions were done totally. Results: In the 5.5 years, in 116 cases 445 TPE and 391 DFPP sessions were done. The mean age was 46.61±16.83 years. There were 49 female and 67 male patients. Guillain-Barre syndrome ( 8.6%) was the commonly encountered indication for neurological diseases, glomerulonephritis ( 25%) was the leading indication for the renal-related diseases. Skin involvement due to diabetes mellitus (13.8%) and Pemphigus Vulgaris (5.2%) were the dermatological diseases. Complication rates were similar between DFPP and TPE sessions (p= 0.411). Conclusion: TPE and DFPP are safe and vital membrane separation techniques used as a treatment for a wide spectrum of diseases. These treatments can be safely done in hemodialysis units intensive care units and DFPP should be considered for the therapy refractory neurological diseases.
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- 1. Stegmayr B, Ramlow W, Balogun RA . Beyond Dialysis: Current and Emerging Blood Purification Techniques. Semin. Dial. 2012; 25: 207–13.
- 2. Williams M E, Balogun RA. Principles of separation: Indications and therapeutic targets for plasma exchange. Clinical Journal of the American Society of Nephrology 2014; 9: 181–90.
- 3. Padmanabhan A, Connely- Smith L, Aquio N, et al. Guidelines on the Use of Therapeutic Apheresis in Clinical Practice - Evidence-Based Approach from the Writing Committee of the American Society for Apheresis: The Eighth Special Issue. J. Clin. Apher. 2019; 34: 171–354.
- 4. Malchesky PS, Koo AP, Roberson GA, et al. Apheresis technologies and clinical applications: The 2005 International Apheresis Registry. Ther. Apher. Dial. 2007; 11: 341–62.
- 5. Alkhatib Y, Dadla A, Melik D., et al. Plasmapheresis and Myeloma Cast Nephropathy: A Meta-Analysis and Review of Evidence. Blood 2017; 130: 5415.
- 6. Li Q Y, Yu F, Zhou FD, et al. Plasmapheresis is associated with better renal outcomes in lupus nephritis patients with thrombotic microangiopathy a case series study. Med. 2016; 95: e3595.
- 7. Filler G, Clark WF, Huang SHS. Tandem hemodialysis and plasma exchange. Pediatr. Nephrol. 2014; 29: 2077–82.
- 8. Şeker YT, Hergünsel OG, Bilgi, DÖ. Therapeutic plasmapheresis: an eleven-year clinical experience. Eur. Res. J. 2018; 4: 343–48.
- 9. Yilmaz AA, Can OS, Oral M, et al. Therapeutic plasma exchange in an intensive care unit (ICU): A 10-year, single-center experience. Transfus. Apher. Sci. 2011; 45: 161–6.
- 10. Stegmayr B, Tärnvik A. Complement activation in plasma exchange by single filtration and centrifugation and in cascade filtration. Blood Purif. 1989; 7: 10–15.
- 11. Lyu RK, Chen W H, Hsieh S T. Plasma exchange versus double filtration plasmapheresis in the treatment of Guillain-Barré syndrome. Ther. Apher. 2002; 6: 163–6.
- 12. Hirano R, Namazuda K, Hirata N. Double filtration plasmapheresis: Review of current clinical applications. Therapeutic Apheresis and Dialysis.2021; 25: 145–51.
- 13. Maxted AP, Connell R, Hussain F. Double filtration plasmapheresis – 10-year pediatric experience as an alternative to plasma exchange. Transfus. Apher. Sci.2020; 59: 1029-8.
- 14. Clark WF. Plasma exchange for renal disease: Evidence and use 2011. in Journal of Clinical Apheresis 2012; 27: 112–6.
- 15. Walsh M , Catapano F, Szpirt W, et al. Plasma exchange for renal vasculitis and idiopathic rapidly progressive glomerulonephritis: A meta-analysis. Am. J. Kidney Dis.2011; 57: 566–74.