Monika GUPTA, Nilay NİSHİTH

Nodular Lymphocyte Predominant Hodgkin Lymphoma With Sarcoid-Like Granulomas: A Rare Association

Granulomatous inflammation is commonly seen in Hodgkin lymphoma. However; the recent literature fails to correlate the subtypes of HL with granuloma. An occasional report describes association of mixed cellularity classical Hodgkin lymphoma with granulomatous reaction. None of other variants of HL are known to manifest with granulomatous reaction. We report a 34-year-old female patient who presented with swelling in right under arm for four months with no history of fever or weight loss. Fine needle aspiration cytology of axillary swelling revealed reactive lymphadenitis. To confirm the diagnosis lymph nodes excision was performed. Histomorphological examination revealed effacement of lymph node architecture by small to intermediate sized lymphoid cells with interspersed mononuclear Reed Sternberg cells like cells along with confluent and discrete non caseating granulomas. Additionally, immunohistochemical staining was performed, which rendered a diagnosis of nodular lymphocyte predominant Hodgkin lymphoma with granulomatous inflammation. This association is uncommon thereby making it pertinent for us to report this rare pathological entity also emphasis on careful microscopic evaluation of lymph node particularly with granulomatous reaction.

Anahtar Kelimeler:

Hodgkin lymphoma, Granuloma, Sarcoidosis

Histopathological Analysis of The Eye And Optic Nerve Structure In The Blind Mole Rat

Objective: Blind mole rats (Nannospalax xanthodon Nehring, 1898) are subterranean mammals that are well-known for their high tolerance to hypoxia and resistance to cancer. Due to their unusual habitat, these animals have developed several adaptations during their evolution. Therefore, this study aimed to identify possible structural differences in Nannospalax visual system in comparison to other mammals that might have arisen as a result of adaptation to underground life. Method: Six blind mole rats were used in the study. No procedure was performed on the rats. After the animals were anesthetized with ether, their eyes and optic nerves were removed. For this purpose, pseudo-eyes and optic nerves were harvested and fixed in 10% formaldehyde for a week. Tissues were embedded into paraffin and blocked via routine histological procedures. Five micrometer sections in thickness were taken and stained with Hematoxylin & Eosin (H&E) and Cresyl Violet. Results: Histopathological analysis of the eye revealed the presence of cornea, retina, sclera, iris, zonula adherens, lacrimal gland and ducts, fatty tissue, muscle layer and the vascular structures. No pathology was observed of optic nerve. Conclusions: We found that the visual system of N. xanthodon share some similarities with other blind mole rat species from Israel, while some histological properties were defined by our study for the first time in the literature.

Keywords:

Nannospalax xanthodon, blind mole rat eye, lacrimal system, optic nerve,

PDF

___

1. Pai K, Sharma S, Padmapriya J. Florid granulomatous response masking diagnosis of Hodgkin’s disease in FNA cytology: a diagnostic challenge. Int J Health Sci Res. 2015; 5:468-470.
2. Shanbhag S, Ambinder RF. Hodgkin Lymphoma: A Review and update on Recent Progress. CA Cancer J Clin.2018;68:116-32.doi: 10.3322/caac.21438 PMID: 29194581
3. Lee AI, Lacasce AS. Nodular lymphocyte predominant Hodgkin Lymphoma.The Oncologist.2009;14:739-51. PMID:19605845 DOI:10.1634/theoncologist 2009-0099.
4. Shah KK, Pritt BS, Alexander MP.Histopathological review of granulomatous inflammation. Journal of Clinical Tuberculosis and other Mycobacterial Diseases.2017;7:1-12. http://dx.doi.org/10.1016/j.jctube.2017.02.001