Serdar ERKASAP, Eda ÖZÇELİK, Sema Uslu, Mehmet KARA, Nilüfer ERKASAP

Kolerektal kanserli hastalarda serum adipositokin düzeyleri

Amaç: Yağ dokusu, bir enerji deposu olan ana işlevinin yanında, bazı sitokinler salgılayarak bir endokrin organ olarak kabul edilir. Leptin ve rezistin, enerji homeostazisinde, glikoz, lipid metabolizmasında ve vücut ağırlığının düzenlenmesinde önemli bir rol oynamaktadır. Bu çalışmanın amacı, kolorektal kanserli hastalarda operasyon öncesi ve operasyon sonrası dönemlerde leptin ve rezistin konsantrasyonlarının belirlenmesidir. Gereç ve yöntem: Toplam 12 kolorektal kanserli hastada ameliyet öncesi ve sonrası dönemde ve yaş ve cinsiyet uyumlu 12 kişiden oluşan kontrol grubunda vücut kitle indeksi (VKİ) ve kan örneklerinde leptin ve rezistin düzeyleri ölçüldü. Serum leptin ve rezistin konsantrasyonları ELISA ile yöntemi ile ölçüldü. Bulgular: Operasyon öncesi grup (leptin: 1.95±0.62 ng/ml; resistin 4.32±1.83 ng/ml) kontrol grubuna (leptin: 6.12±0.82 ng/ml; resistin: 10.75±1.46 ng/ml) göre karşılaştırıldığında leptin ve rezistin düzeylerinde azalma gözlemlendi (sırasıyla, p

Anahtar Kelimeler:

Kolorektal kanser, leptin, rezistin, serum

Serum adipocytokine levels in patients with colorectal cancer

Objectives: Adipose tissue, besides its main function as an energy storage depot, is currently considered an endocrine organ that secretes several self-produced cytokines. Leptin and resistin play an important role in energy homeostasis, glucose, lipid metabolism and regulation of body weight. The aim of the current study was to determine the concentration of leptin and resistin in pre-operational and post-operational periods of patients diagnosed as colorectal cancer. Materials and methods: The body mass index (BMI) and values of leptin and resistin in blood at diagnosis were measured in 12 colorectal cancer patients in pre- and post-operational periods and in 12 age- and sex-matched controls. Serum leptin and resistin concentrations were measured by ELISA method. Results: Decreased leptin (1.95±0.62 ng/ml) and resistin (4.32±1.83 ng/ml) levels were found in pre-operational group compared with the control group (leptin: 6.12±0.82 ng/ml; resistin: 10.75±1.46 ng/ml) (p

Keywords:

Colorectal neoplasm, leptin, resistin serum,

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