Objective: In this study, it was aimed to examine the experience, knowledge, and awareness of dentists about adverse drug effects and pharmacovigilance. Methods: In this cross-sectional and descriptive study, a 15-question questionnaire was applied to 100 dentists who are working at Diyarbakir Oral and Dental Health Hospital to evaluate their knowledge, attitudes and practices about adverse effects and pharmacovigilance. Results: 55 percent of dentists stated that they had never encountered an adverse drug reaction (ADR) in their professional life. Even though 45 percent of them reported that they have rarely seen ADR in their professional life, the total number of declarations has been determined as 7.78% of dentists are aware that declaration is required and this is a professional responsibility (86%). Physicians stated that they had no idea how to report ADRs with their current knowledge (81%) and subject of pharmacovigilance was not well covered in the dental education (55%). 86% of them stated that education on this subject should be taken at undergraduate level (internship, education, clinical assignment) and 58% stated that it should be taken in their working life after graduation. Conclusion: This study showed that the dentists participating in the study had a lack of awareness and knowledge about pharmacovigilance and ADR. It was observed that the rate of ADR reporting among physicians was very low compared to the encounter rate. Inclusion of pharmacovigilance in the educational program and providing pre- and post-graduate training to dentists for declaration practices can contribute positively to public health.