Hamdi PÜŞÜROĞLU, Mehmet ERTÜRK, Özgür AKGÜL, Özgür SÜRGİT, İsmail BOLAT, Emre AKKAYA, Aydın YILDIRIM

Hipertansif hastalarda N- amino terminal prohormon beyin natriüretik peptid düzeyleri ile ilişkili faktörler

Amaç: N- amino terminal prohormon beyin natriüretik peptid (NT-pro BNP) ise genel popülasyonda hem kalp yetersizliği gelişimi hem de kardiyovasküler olay gelişiminin öngörücüsüdür. Biz bu çalışmada hipertansif hasta toplumunda NT-pro BNP düzeyini etkileyen faktörleri araştırdık. Yöntemler: Çalışmaya yaş ortalaması 50,5 ± 10,7 olan toplam 309 hipertansif hasta alındı. Hastaların % 49,2 erkeklerden oluşmaktaydı. NT-pro BNP değeri 60 pg/dl nın üzerinde olanlar yüksek grup (110 kişi) 60 ve altında olanlar ise düşük grup olarak belirlendi (199 kişi). Kalp yetersizliği, orta-ileri kapak hastalığı, koroner arter hastalığı, aritmi, kronik böbrek yetersizliği, kronik obstrüktif akciğer hastalığı olanlar ve sekonder hipertansiyonu olan hastalar çalışmaya alınmadı. Bulgular: Sol ventrikül kitle indeksi, 24 saatlik, gündüz ve gece sistolik kan basıncı ve gece diyastolik kan basıncı yüksek grupta daha yüksek ölçülmüştü. Stepwise liner regresyon analizinde, cinsiyet, sol ventrikül kitle indeksi, yaş ve gece sistolik kan basıncının yüksek NT-pro BNP düzeylerinin bağımsız öngörücüleri oldukları tespit edildi (sırasıyla, R²=0.236, ß= -0,258, P

Factors associated with the levels of N- amino terminal prohormone brain natriuretic peptid in hypertensive population

Objective: In this study we ınvestigated that which the factors affecting the level of N- amino terminal prohormone brain natriuretic peptid (NT-pro BNP) in hypertensive population. Methods: A total of 309 hypertensive patients (mean age 50.5 ± 10.7, 49.2% male) were enrolled into the study. Lower group was defined as NT-pro BNP 60 pg/dl or low, high group was defined as NT-pro BNP 60 pg/dl higher. The patients with secondary hypertensive, heart failure, coronary artery disease, valvular diseases, chronic renal failure (serum creatinine >1.5 mg/dl, blood urea nitrogen>30 mg/dl) and chronic obstructive pulmonary disease were excluded from the study. Results: Left ventricular mass index, 24-h systolic blood pressure, day systolic blood pressure, night systolic blood pressure and night diastolic blood pressure higher in high group than lower group. In stepwise linear regression analysis, a significant relation was found between sex, left ventricular mass index, age, night systolic blood pressure and higher NT-pro BNP levels (R²=0.236, ß= -0.258, P<0.001, ß=0.185, P=0.006, ß=0.174, P=0.010, ß=0.160, p=0.015 respectively). Conclusion: Age, gender, left ventricle mass index and night systolic blood pressure were found as independent predictive factors on NT-pro BNP in hypertensive patients.

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