Gebelik anemisinin perinatal sonuçlara etkisi

Gebelikte tedavi edilmemiş aneminin yenidoğanda komplikasyonlar ile ilişkili olabileceği bildirilmektedir. Çalışmamızın amacı gebelikte maternal anemi tespit edilen hastalardaki perinatal sonuçları değerlendirmektir. Çalışmaya ikinci trimesterde hemoglobin (Hb) düzeyi 8 g/dl’nin altında olan 29 anemik gebe kadın (Grup 1) ile Hb düzeyi 10 g/dl’nin üzerinde olan 30 gebe kadın (Grup 2) dahil edildi. Her iki grup için preterm doğum, intrauterin gelişme geriliği (IUGG) ve yeni doğan ünitesine sevkedilme oranları incelendi. Grup 1 de ortalama Hb konsantrasyonu 7.2±0.4 gr/dl, Grup 2 de 12.1±0.9 olarak saptandı (P0.05), yeni doğan ünitesine sevk oranı anemik grupta anlamlı yüksek bulundu (sırasıyla %44.8 ve %166, P=0.019). Gebelik anemisinin antenatal takipler sırasında belirlenmesi ve tedavisi perinatal komplikasyonların azaltılması bakımından önemlidir. Maternal aneminin perinatal sonuçlara etkileri açısından daha ileri çalışmalara ihtiyaç vardır.

The effects of gestational anemia on perinatal outcomes

Untreated anemia during pregnancy is reported to be associated with fetal complications. The aim of present study was to investigate perinatal outcomes associated with maternal anemia during pregnancy. Twenty-nine pregnant women with second trimester hemoglobin (Hb) levels under 8 g/dL (Group 1) and 30 over 10 g/dL (Group 2) were included. The ratios of preterm birth, intrauterine growth restriction (IUGR) and admission to neonatal intensive care unit (NICU) were recorded. Preterm birth ratio was 34,4% in Group 1 and 13.3% in Group 2 (P=0.05). There was no significant difference in IUGR between two groups (P>0.05). Neonatal care unit admissions were significantly higher in Group 1 compared with Group 2 (44.8% vs. 16.6%, respectively, P=0.019). Diagnosis and treatment of maternal anemia during pregnancy is important to minimize the perinatal complications. Further studies are necessary to evaluate the association of maternal anemia and perinatal outcomes more clearly.

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  • 1. World Health Organization. The prevalence of anemia in women: a tabulation of available information.2nded.Geneva, Switzerland, WHO, 1992.
  • 2. Hytten F, Paintin DB. Increase in plasma volume during normal pregnancy. J Obstet Gynaecol 1963;70:402-427.
  • 3. Steer PJ. Maternal hemoglobin concentration and birth weight. Am J Clin Nutr 2000;71:1285-1287.
  • 4. Huisman A, Aarnoudse JG. Increased 2nd trimester hemoglobin concentration in pregnancies later complicated by hypertension and growth retardation. Early evidence of a reduced plasma volume. Acta Obstet Gynecol Scand 1986;65:605-608.
  • 5. Stephansson O, Dickman PW, Johansson A, Cnattingius S. Maternal hemoglobin concentration during pregnancy and risk of stillbirth. JAMA 2000;284:2611-2617.
  • 6. Levy A, Fraser D, Katz M, Mazor M, Sheiner E. Maternal anemia during pregnancy is an independent risk factor for low birthweight and preterm delivery. Eur J Obstet Gynecol Reprod Biol 2005;122:182-186.
  • 7. Bondevik GT, Lie RT, Ulstein M, Kvale G. Maternal hematological status and risk of low birth weight and preterm delivery in Nepal. Acta Obstet Gynecol Scand 2001;80: 402-408.
  • 8. Lone FW, Qureshi RN, Emmanuel F. Maternal anaemia and its impact on perinatal outcome in a tertiary care hospital in Pakistan. East Mediterr Health J 2004;10:801-807.
  • 9. Malhotra M, Sharma JB, Batra S, Sharma S, Murthy NS, Arora R. Maternal and perinatal outcome in varying degrees of anemia. Int J Gynaecol Obstet 2002;79:93-100.
  • 10. Murphy JF, O’Riordan J, Newcombe RG, Coles EC, Pearson JF. Relation of haemoglobin levels in first and second trimesters to outcome of pregnancy. Lancet 1986;1:992-995.
  • 11. Lu ZM, Goldenberg RL, Cliver SP, Cutter G, Blankson M. The relationship between maternal hematocrit and pregnancy outcome. Obstet Gynecol 1991;77:190-194.
  • 12. Blankson ML, Goldenberg RL, Cutter G, Cliver SP. The relationship between maternal hematocrit and pregnancy outcome: blackwhite differences. J Natl Med Assoc 1993;85:130-134.
  • 13. Patra S, Pasrija S, Trivedi S, Puri M. Maternal and perinatal outcome in patients with severe anemia in pregnancy. Int J Gynecol Obstet 2005;91:164-165.