Soner OFLAZOĞLU, Levent ŞAHİN, Ömer AKTAŞ, Mehrican ŞAHİN, Sibel OBA

Farelerde lornoksikam ile parasetamol’ün preemptif analjezik etkinliğinin karşılaştırılması

Preemptif analjezi, ağrılı uyarıdan önce bir analjezik rejiminin uygulanarak periferik ve santral nosisepsiyonun bloke edilmesi anlamına gelmektedir. Biz bu deneysel çalışmamızda fareler üzerinde parasetamol ile lornoksikamın preemptif analjezik özelliklerini karşılaştırmayı amaçladık. Gereç ve yöntem: Fareler üç gruba ayrıldı. Farelerin sağ ön ayağına formalin enjeksiyonundan önce birinci gruba intraperitoneal serum fizyolojik, ikinci gruba lornoksikam ve üçüncü gruba parasetamol enjekte edildi. İşlem sonrası 60 dk boyunca farelerin ağrı cevabı kaydedildi. Bulgular: İlk 10 dk’da lornoksikamın kontrol grubuna göre daha etkin olduğu görünürken, 11-60.dk ve 0-60. dk dikkate alındığında parasetamolün lornoksikamdan ve kontrol grubundan daha etkin bir analjezi sağladığı görülmüştür. Sonuç: Çalışmamızda akut fazda lornoksikamın parasetamole göre anlamlı fayda sağlamasına karşın tonik fazda ve toplam sürede parasetamol daha etkin bulunmuştur.

The comparison of efficacy of lornoxicam and paracetamol for preemptive analgesia in mice

Preemptive analgesia means that block the peripheral and central nociception as an analgesic regime apply before the painful stimulus. We aimed compared preemptive analgesic properties of lornoxicam with paracetamol on mice in this experimental study. Materials and methods: Experimental mice were divided into three groups. Before the formalin injection in the right front foot of mice, saline administered in first group, lornoxicam administered in second group and paracetamol in third group intraperitoneally. Responses to pain of mice were recorded after the procedure during the 60 min. Results: While appears to be lornoxicam more effective than the control group in the first 10 minutes, paracetamol provided more effective analgesia lornoxicam and control group within 11-60th min. and 0-60th min. Conclusion: Although lornoxicam provided significant benefit in acute phase, paracetamol was found more effective in tonic phase and total time in this study.

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