Objectives: Chronic obstructive pulmonary disease (COPD) is a difficult chronic illness to manage because it causes prolonged hospital admissions and repeated applications. We aimed to examine the factors affecting this situation in a winter emergency in a chest diseases emergency. Material and Method: We conducted a retrospective study in our emergency department (ED) with patients who admitted due to COPD exacerbations. Factors affecting hospitalization and ICU requirement were evaluated. Results: Totally 128 patients were included. Mean number for ED admissions was 3.01±2.1. There were 73 (57%) hospitalized patients and 17(13.3%) patients transferred to intensive care unit (ICU). White blood cell (WBC) and C reactive protein (CRP) were significantly higher in patients with ≥3 ED admissions than others (p=0.06 and p=0.007 respectively). Among categorical variables being current smoker, long time oxygen therapy (LTOT) and non-invasive mechanical ventilation (NIMV) devices and existence of bronchiectasis were related to frequent ED admission (p=0.025, p=0.01, p=0.046 and p=0.028 respectively). Existence of pneumonia and comorbidities had positive and significant correlations with hospitalization (r=0.18, p=0.04 and r=0.26, p=0.02). In terms of ICU requirement, pneumonia, partial arterial pressure of carbon dioxide (PaCO2) value and mean pulmonary arterial pressure (PAB) had significant correlations (r=0.27, p=0.001, r=0.34, p
Giriş: Kronik obstrüktif akciğer hastalığı (KOAH), tekrarlayan acil başvurusu ve uzamış hastane yatışlarına neden olduğu için tedavisi zor bir kronik hastalıktır. Bir kış döneminde göğüs hastalıkları acilinde KOAH atak seyrini etkileyen faktörleri incelemeyi amaçladık. Yöntemler: KOAH alevlenmeleri nedeniyle acil servisimize başvuran olgularla retrospektif bir çalışma gerçekleştirdik. Sık acil başvurusu, hastaneye yatış ve yoğun bakım ünitesi (YBÜ) gerekliliğini etkileyen faktörler değerlendirildi. Bulgular: Toplam 128 hasta dahil edildi. Ortalama acil başvuru sayısı 3.01 ± 2.1 idi. Hastaların 73'ü (% 57) hastaneye yatırıldı ve 17'si (% 13.3) YBÜ transfer edildi. Beyaz küre ve C-reaktif protein (CRP), 3 den fazla acil başvurusu olan hastalarda diğerlerine kıyasla anlamlı olarak yüksekti (p= 0.06 ve p= 0.007 sırasıyla). Aktif sigara kullanımı, uzun süreli oksijen tedavisi (USOT) ve non-invaziv mekanik ventilasyon (NIMV) cihazları ve bronşektazi varlığı sık acil başvurusu ile ilişkili saptandı (Sırasıyla p= 0.025, p= 0.01, p= 0.046 ve p= 0.028). Zatürree ve komorbiditelerin yatış ile pozitif ve anlamlı korelasyonları vardı (r= 0.18, p = 0.04 ve r= 0.26, p= 0.02). Yoğun bakım gereksinimi açısından pnömoni, Parsiyel arteriyel karbondioksit basıncı (PaCO2) değeri ve ortalama pulmoner arter basıncı (PAB) arasında anlamlı korelasyonlar vardı (Sırasıyla r= 0.27, p= 0.001; r=0.34, p
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1.Global Initiative for Chronic Obstructive LungDisease (GOLD). Global strategy for the diagnosis,management, and prevention of chronic obstructivepulmonary disease (2019 report) [Internet]. EUA:GOLD; 2019 [cited 2018 Dec 7]. Available from:https://goldcopd.org/wp-content/uploads/2018/11/GOLD-2019-v1.7-FINAL-14Nov2018-WMS.pdf.
2.Zhang Y, Lin YX. Risk factors analysis for one-yearand long-term mortality in patients hospitalized foracute exacerbation of chronic obstructivepulmonary disease. Zhonghua Jie He He Hu Xi Za Zhi.2019; 42: 895-900.
3.Steriade AT, Davidoiu A, Afrasinei A, et al.Predictors of Long-term Mortality afterHospitalization for Severe COPD Exacerbation.Maedica (Buchar). 2019; 14: 86-92.
4.Casas-Mendez F, Abadías MJ, Yuguero O, et al.Treatment strategies after acute exacerbations ofchronic obstructive pulmonary disease: Impact onmortality. PLoS One. 2018; 12: e 0208847.
5.Civelek C, Korkmaz İ, Eren ŞH, et al. Kronikobstruktif akciğer hastalığı akut alevlenmelihastalarda prokalsitonin ve diğer akut fazbelirteçleri. Dicle Tip Derg. 2011;38: 137-42.
6.Overbeek JA, Penning-van Beest FJ, Balp MM, et al.Burden of Exacerbations in Patients with Moderateto Very Severe COPD in the Netherlands: A Real-lifeStudy. COPD. 2014; 12: 132-43.
7.Rehman AU, Ahmad Hassali MA, et al. Theeconomic burden of chronic obstructive pulmonarydisease (COPD) in the USA, Europe, and Asia: resultsfrom a systematic review of the literature. ExpertRev Pharmacoecon Outcomes Res. 2019; 18: 1-12.
8.Kim J, Rhee CK, Yoo KH, et al. The health careburden of high grade chronic obstructive pulmonarydisease in Korea: analysis of the Korean HealthInsurance Review and Assessment Service data. Int JChron Obstruct Pulmon Dis. 2013; 8: 561-8.
9.Hurst JR, Vestbo J, Anzueto A, et al. Evaluation ofCOPD Longitudinally to Identify PredictiveSurrogate Endpoints (ECLIPSE) Investigators.Susceptibility to exacerbation in chronic obstructivepulmonary disease. N Engl J Med. 2010; 363: 1128-38.
10.Abadias Medrano MJ, Torres OY, Robles IB, et al.Exacerbations of chronic obstructive pulmonarydisease. An analysis of the care process in a regionalhospital emergency department. Medicine 2018;97:e11601
11.Budde J, Agarwal P, Mazumdar M, et al. Can anEmergency Department Observation Unit ReduceHospital Admissions for COPD Exacerbation? Lung.2018; 196: 267–0.
12.Pethyabarn W, Chewae S, Dadeh AA. FactorsAssociated with Treatment Failure in Patients withAcute Exacerbation of COPD Admitted to theEmergency Department Observation Unit. EmergMed Int. 2020: 8261375.
13.Alqahtani JS, Njoku CM, Bereznicki B, et al. Riskfactors for all-cause hospital readmission followingexacerbation of COPD: a systematic review andmeta-analysis. Eur Respir Rev. 2020; 29: 190166.
14.Groenewegen KH, Schols AM, Wouters EF.Mortality and mortality-related factors afterhospitalization for acute exacerbation of COPD.Chest. 2003; 124: 459-67.
15.Ranieri P, Bianchetti A, Margiotta A, et al.Predictors of 6-month mortality in elderly patientswith mild chronic obstructive pulmonary diseasedischarged from a medical ward after acutenonacidotic exacerbation. J Am Geriatr Soc. 2008;56: 909-13.
16.Shin HJ, Park CK, Kim TO, et al. Differentcharacteristics associated with intensive care unittransfer from the medical ward between patientswith acute exacerbations of chronic obstructivepulmonary disease with and without pneumonia. JThorac Dis. 2016; 8: 1121-31.
17.Satıcı MO, Aksel G, Satıcı C, et al. Adherence ofEmergency Medicine Physicians to the GOLD Reportin Management of COPD Exacerbation. Anatolian JEmerg Med. 2020; 3; 42-46.