Yrd. Doç. Dr. Cankat KARA, Dr. Hatice YAĞIZ, Dt. Meltem ZİHNİ

NİFEDİPİN TEDAVİSİNE BAĞLI ORTAYA ÇIKAN

Nifedipin, arteriyal hipertansiyon ve angina pektoris tedavisinde s kl kla kullan lan bir ajand r. Nifedipine ba2l oral komplikasyonlar geli ebilir ki, bunlardan di eti büyümesi en önemlilerindendir. Bu çal ma, koronor arterlerin dilatasyonunda kullan lan önemli bir ilaç olan nifedipinin uzun dönem kullan m na ba2l geli en di eti büyümesi ikayetiyle klini2imize ba vuran bir bayan hastan n vaka raporudur. Vakada büyüyen di eti dokular n n cerrahi olarak uzakla t r lmasve dikkatli plak kontrolü ile ilac n kullan m n nkesilmesine gerek duyulmadan yeterli iyile mesa2lanm t r. Bu çal mada nifedipine ba2l geli en di eti büyümesinin klinik özellikleri, etiolojisi, ay r c tan s ve tedavisi, konuyla ili kili kaynaklar 2 nda tart lm t r

Anahtar Kelimeler:

Nifedipin, Di eti Büyümesi

NİFEDİPİN TEDAVİSİNE BAĞLI ORTAYA ÇIKAN

Keywords:

-,

PDF

___

Brunet L, Miranda J, Farre M, Berini L, Mendieta C. Gingival enlargement induced by drugs. Drug Saf. 1996;15(3):219–31.
Tack DA, Rogers RS. Oral drug reactions. Dermatologic Therapy 2002;15: 236–250.
Desai P, Silver JG: Drug-induced gingival enlargements. J Can Dent Assoc.1998; 64(4):263–268.
Ciantar M. Nifedipine-induced gingival overgrowth: remission following non-surgical therapy. Dent Update. 1996;23(9):374–377.
Katz J, Rotstein I, Ben Yehuda A, Barak S. Nifedipine-induced gingival hyperplasia. Ann Dent.1992;51(1):5–7.
Bokor-Bratic M, Vuccovic N, Selakovic S. Gingival hyperplasia during treatment with nifedipine: Med Pregl. 1998;51(9–10): 445– 448.
Angelopolous AP, Goaz PW. Incidence of diphenylhydantoin gingival hyperplasia. J Oral Surg 1972; 34: 898–906.
Barak S, Engelberg IS, Hiss J. Gingival hyperplasia caused by nifedipine (Histopathologic findings). J Periodontol 1987; 58(9): 639–642.
Thomason JM, Seymour RA, Rice N. The prevalence and severity of cyclosporin and nifedipine-induced gingival overgrowth. J Clin Periodontol 1993;20(1):37–40.
Thomason JM, Seymour RA, Ellis JS, Kelly PJ, Parry G, Dark J, Idle JR. Iatrogenic gingival overgrowth in cardiac transplantation. J Periodontol 1995; 66: 742–746.
Hassell TM, Hefti AF. Drug-induced overgrowth: Old problem, new problem. Crit Rev Oral Biol Med 1991; 2: 103–137.
Nishikawa S.,Tada H., Hamasaki A.,et al. Nifedipine-induced gingival hyperplasia: A clinical and in vitro study. J Periodontol 1991; 62: 30–35.
Hassell T, Sobhani S. Effects of diphydropyridines on connective tissue cells in vitro. J Dent Res 1987; 66 (Spec. Issue): 282(Abstr. 1401).
Heijl L, Sundin Y. Nifedipine-induced gingival overgrowth in dogs. J Periodontol 1988; 60: 104–112.
Bullon P, Machuca G, Armas JR, Rojas JL, Jimenez G. The gingival inflammatory infiltrate in cardiac patients treated with calcium antagonists. J Clin Periodontol 2001; 29: 897– 90.