Dr.gülser KILINÇ, Dr.gülçin BULUT, Prof. Dr. Nur OLGUN, Dr. Bengü DEMİRAĞ, Prof. Dr. Gülersu İRKEN, Prof. Dr. Fahinur ERTUĞRUL, Prof. Dr. Nesrin ERONAT

Kanser Tedavisi Gören Çocuklarda Tedavinin Diş Gelişimine Olan Geç Yan Etkileri (Dört Olgu Sunumu)

Kanser tedavisi gören çocuklarda erken yaşlarda uygulanan kemoterapi ve radyoterapinin daimi diş gelişimi üzerine yan etkileri bilinmektedir. Çocuklarda görülen bu dental problemler hipodonti, mikrodonti, taurodontizm, temporamandibuler eklem bozuklukları, maloklüzyon kök gelişiminin durması ve mine hipoplazisi olarak sıralanabilir. Bu çalışmanın amacı, kanser tedavisi görmüş dört çocuk hastada, kemoterapi ve radyoterapinin daimi dişler üzerine olan geç yan etkilerini sunmaktır. Üç yaşından önce kanser teşhisi konulmuş dört çocuk hasta oral ve radyolojik muayeneleri için iki sağlık (Dokuz Eylül Üniversitesi Hastanesi, Behçet Uz Çocuk Hastanesi) merkezinin çocuk diş kliniğinde incelenmiştir. Hastaların biri nöroblastoma, diğeri şeffaf hücreli sarkom, ikisi akut lemfoblastik lösemi tedavisi görmüştür. Kemoterapi ve radyoterapi tedavisinin üzerinden en az beş yıl geçtikten sonra yapılan oral ve radyolojik incelemede, mikrodonti, hipodonti ve mine hipoplazileri gözlenmiştir. Hastanın yaşı, uygulanan tedavinin tipi ve dozu diş yapısını etkileyebilmektedir. Küçük yaş gruplarında kanser tedavisi gören çocukların ebeveynlerini, ileride oluşabilecek dental sorunlar ve etkileri hakkında bilgilendirmek oldukça önemlidir.

Anahtar Kelimeler:

Kemoterapi; radyoterapi; diş gelişimi; mikrodonti; hipodonti

Dental Development Abnormalities After Cancer Therapy İn Childhood (Four Case Reports)

In childhood cancer survivors’ cases, it is well known that treatments with chemotherapy and radiotherapy have side effects on permanent tooth development. Hypodontia, microdontia, taurodontism, temporamandibular joint disorders, malocclusion, root stunting and enamel hypoplasia can be considered as disturbances in dental development in children. The aim of the study is to present the longterm effects of chemotherapy and radiotherapy on permenant dentition in four childhood cancer survivors cases. Four childhood cancer survivors patients diagnosed under age three were examined in two health centers (Dokuz Eylül University Hospital and Dr.Behcet Uz Children’s Hospital) for oral and radiographic diagnosis. One of the four is neuroblastoma, another is, remaing two clear cell sarcoma have had therapy for acute lymphoid leukemia. Microdontia, hypodontia and enamel hypoplasia have been observed in oral and radiographic examinations after completing at least 5 years following the chemotherapy and radiotherapy. The age of the patient having therapy, type and dosage of the therapy can influence the structure of the teeth. For this reason, it is important to inform the parents of children who will receive cancer therapy in young ages about the effects and consequences of therapy on dental development.

Keywords:

Chemotherapy, radiotherapy, dental development, microdontia hypodontia.,

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Dokuz Eylül Üniversitesi Hastanesi, Çocuk Diş Kliniği, İzmir, TÜRKİYE Tel: 0232-4122185, 0532-4248756 e-mail: gulser.kilinc@deu.edu.tr