___

• Newman HN. Focal sepsis- modern concept. J Ir Dent Assoc 1968;14:53-63.
• Newman HN. Focal infection. J Dent Res 1996;75:1912-9.
• Li X, Kolltveit K, Tronstad L, Olsen I. Systemic diseases caused by oral infection. Clin Microbiol Rev 2000;13:547-558.
• Gibbs RS. The relationship between infections and adverse pregnancy outcomes:an overview. Ann Periodontol 2001;6:153-63.
• de Soet JJ, Schriks MCM, Kratz E, Poland DCW, van Dijk W, van Amerongen WE. Dental caries related to plasma IgG and alpha1 – acid glycoprotein. Caries Res 2003; 37:79-84.
• Yoshihara A, Hanada, Miyazaki H. Association between serum albumin and root caries in community-dwelling older adults. J Dent Res 2003;82:218-222.
• Hahn CL, Best AM, Tew JG. Comparison of Type 1 and Type 2 Cytokine production by mononuclear cells cultured with Streptococcus mutans and selected other caries bacteria. J Endodon 2004;30:333-8.
• Izumi T, Kobayashi I, Okamura K, Matsuo K, Kiyoshima T, Ishibashi Y, Inoue H, Sakai H. An immunohistochemical study of HLA-DR and alpha 1-antichymotrypsin-positive cells in the pulp of human non-carious and carious teeth. Arch Oral Biol 1996;41:627-30.
• Hahn CL, Best AM, Tew JG. Cytokine Induction by Streptococcus mutans and pulpal pathogenesis. Infect Immun 2000;68:6785-89.
• Baum LJ. Dental pulp conditions in relation to carious lesions. Int Dent J 1970;20:309.
• Ivanyi L, Lehner T. The relationship between caries index and stimulation of lymphocytes by Streptococcus mutans in mothers and their neonates. Arch Oral Biol 1978;23:851-6.
• Izumi T, Kobayashi I, Okamura K, Sakai H. Immunohistochemical immunocompetent cells of the pulp in human non- carious and carious teeth. Arch Oral Biol 1995;40:609-14. study on the
• Moore MA, Gregory RL, Switalski LM, Hakki ZW, Gfell LE, Kowolik MJ. Differential activation of human neutrophils by Streptococcus mutans isolates from root surface lesions and caries-free and caries-active subjects. Oral Microbiol Immunol 1998;13:41-6.
• Jontell M, Okiji T, Dahlgren U, Bergenholtz G. Immun defense mechanisms of the dental pulp. Crit Rev Oral Biol Med 1998;9:179-200.
• Pezelji-Ribaric S, Anic I, Brekalo I, Miletic I, Hasan M, Simunovic-Soskic M. Detection of tumor necrosis factor alpha in normal and inflamed human dental pulps. Arch Med Res 2002;33:482-4.
• Nakanishi T, Matsuo T, Ebusi S. Quantitative analysis of immunoglobulins and inflammatory factors in human pulpal blood from exposed pulps. J Endod 1995;21:131-6.
• Challacombe SJ, Bergmeier LA, Rees AS. Natural antibodies in man to aprotein antigen from the bacterium Streptococcus mutans related to dental caries experience. Arc Oral Biol 1984;29:179-84.
• Parkash H, Sharma A, Banerjee U, Sidhu SS, Sundaram KR. Differential cell-mediated immune response to S. mutans in children with low and high dental caries. Indian Pediatr 1993;30:991-5.
• Aaltonen AS, Tenovuo J, Lehtonen OP, Saksala R. Maternal caries incidence and salivary close- contacts with children affect antibody levels to Streptococcus mutans in children. Oral Microbiol Immunol 1990;5:12-8.
• Geerts SO, Nys M, De MP, Charpentier J, Albert A, Legrand V, Rompen EH. Systemic release of endotoxins induced by gentle mastication: association Periodontol 2002;73:73-8. severity. J
• Zhang P, Jespersgaard C, Lamberty-Mallory L, Katz J, Huang Y, Hajishengallis G, Michalek SM. Enhanced immunogenicity of a genetic chimeric protein consisting of two virulence antigens of Streptococcus mutans and protection against infection. Infect Immun 2002;70:6779-87.