Özlem ŞAHİN, Sami HİZMETLİ, Nalan GÜLER, Ece KAPTANOĞLU, Hasan ELDEN

Fibromiyaljili kadın olgularda gabapentinin etkinliği

Amaç. Biz bu çalışmada fibromiyaljili kadın olguların tedavisinde gabapentinin etkinliğini araştırdık. Yöntem. Fibromiyalji tanısı alan 75 kadın hasta çalışmaya alındı. Hastalar rastgele üç gruba bölündü. Birinci gruba 1200-2400 mg/gün arasında gabapentin; ikinci gruba 25 mg/gün amitriptilin; üçüncü gruba ise plasebo tedavisi uygulandı. Hastalar tedaviden önce ve tedavinin onikinci haftasında aynı hekim tarafından değerlendirildiler. Hassas nokta sayısı saptandı, ağrı, yorgunluk ve sabah tutukluğu için VAS, Beck Depresyon Ölçeği (BDÖ), Pittsburgh Uyku Kalite İndeksi (PUKİ), ve Fibromiyalji Etki Sorgulaması Formu (FIQ) uygulandı. Bulgular. Onikinci haftadaki değerlere bakıldığında her üç grupta da yorgunluk, sabah tutukluğu, hassas nokta sayısı, PUKİ ve FIQ değerlerindeki düzelmeler istatistiksel olarak anlamlı bulundu (p

The effectiveness of gabapentine in female patients with fibromyalgia

Aim. We aimed to search the effectiveness of gabapentin in the treatment of female fibromyalgia patients. Methods. Seventy-five female fibromyalgia patients were included in the study. The patients were randomly assigned to three groups. First group was given gabapentin (1200-2400 mg/day); second group was given amytriptyline (25 mg/day) and the third group was given placebo. Patients were evaluated before and after the 12th week of the treatment by the same doctor. Number of the tender points were counted, VAS for pain, fatigue and morning stiffness were evaluated, and Beck Depression Scale (BDS), Pittsburgh Sleep Quality Index (PSQI) and Fibromyalgia Impact Questionnaire (FIQ) were given to the patients. Results. Considering the results at the 12th week, the improvement in fatigue, morning stiffness, tender point count, PSQI and FIQ were statistically significant in all of the groups (p

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