Ümit M KOCYIGIT

Sıçanların Akciğer Dokusunda Oksitosin ve Oksitosin Reseptör Antagonisti Atosiban’ın Karbonik Anhidraz ve Asetilkolinesteraz Enzim Aktiviteleri Üzerine Etkileri

Çalışmamızda, sıçanlara enjekte edilen oksitosin ve oksitosin reseptör antagonisti olan atosibanın, sıçan akciğer dokusunda karbonik anhidraz (CA) ve asetilkolinesteraz (AChE) enzim aktiviteleri üzerine etkilerinin incelenerek, oksitosinin canlı metabolizmadaki rolünün tam olarak anlaşılmasına yardımcı olmak amaçlanmıştır. Bu amaçla, her biri 6 adet sıçandan oluşan 4 farklı grup oluşturuldu. (Kontrol grubu, oksitosin verilen grup, atosiban verilen grup ve oksitosin ile atosibanın birlikte verildiği grup). Sıçanlara kimyasallar intraperitoneal olarak enjekte edildikten bir saat sonra sıçanlar nekropsiye alındı. Sıçanların akciğer dokuları çıkarıldı. Bu dokular için CA ve AChE aktiviteleri ölçüldü. Tüm deneysel sonuçlar ortalama±SH (ortalamanın standart hatası) olarak ifade edildi. Veriler normal dağılıma uygunluk gösterdiği için varyans analizi (ANOVA) ile test edildi ve daha sonra anlamlılık Tukey test ile belirlendi. İstatistiksel anlamlılık p

The Effects of Oxytocin and Oxytocin Receptor Antagonist Atosiban on the Carbonic Anhydrase and Acetylcholinesterase Enzymes from Lung Tissues of Rats

The purpose of our studies is to assist in fully understanding the role of oxytocin in the live metabolism by examining the effects of oxytocin, oxytocin receptor antagonist atosiban, and oxytocinatosiban chemicals injected to the rats on activities of carbonic anhydrase (CA) and acetylcholinesterase (AChE) enzymes in the lung tissue of the rats. For this purpose, 4 different groups each of which contains 6 rats formed. (Control group, oxytocin administered group, atosiban administered group, and both oxytocin and atosiban administered group). The rats were necropsied after an hour from the injection of chemicals into the rats intraperitoneally. The lung tissues of the rats were extracted. Carbonic anhydrase and acetylcholinesterase enzymes activities were measured for the tissues. All the experimental results were provided as mean ± SD (mean standard deviation). Because of the data was compatible with the normal range, it was tested via variance analysis (ANOVA) and then, significance was determined by the Tukey test. Statistical significance was identified to be p

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