İbrahim BAYRAM, Serhan KÜPELİ, Emine BAGIR, Atila TANYELİ, Banu KOZANOĞLU, Gülay SEZGİN, Ayse ÖZKAN

Secondary Lymphoma in a Patient with a History of Unilateral Retinoblastoma

İkincil malign hastalıklar herediter retinoblastomlu hastalarda artmış bir sıklıkta gelişebilmektedir. Retinoblastom yaşayanlarında en sık rastlanan malign hastalıklar yumuşak doku sarkomları ve osteosarkomdur. İkincil tümör olarak lenfoma gelişmesi ise nadiren bildirilmiştir. Bu yazıda ünilateral retinoblastom nedeniyle enükleayon ve radyoterapi ile tedavi edilen, 12 yıl sonra lenfoma tanısı alan ve heterozigot p.R552 (c.1654C> T) mutasyonu saptanan 13 yaşında bir hasta rapor edilmiştir. İkincil tümör gelişme riski özellikle radyoterapi verilmiş herediter retinoblastomlu hastalarda daha fazladır.

Retinoblastom Öyküsü Olan Bir Hastada İkincil Lenfoma

Second malignancies develop with increased incidence in patients with herediter retinoblastoma. The most common second malignancies in retinoblastoma survivors are soft tissue sarcoma and osteosarcoma. Lymphoma developing as a second malignancy has rarely been reported. Here we report a case of lymphoma diagnosed in a 13 year-old-boy, 12 years after the diagnosis of unilateral retinoblastoma having heterozygous p.R552 (c.1654C> T) mutation, treated with enucleation and radiotherapy. The risk of second tumour is higher in the hereditary retinoblastoma, especially in cases undergoing external beam radiation therapy.

PDF

___

Abramson DH, Schefler AC: Update on retinoblastoma. Retina. 2004;24:828-48.
Aerts I, Rouic LL, Gauthier-Villars M, et al:Retinoblastoma review. Orphanet Journal of Rare Diseases. 2006;1:31.
Knudson AG Jr. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA. 1971;68:820-3.
Friend SH, Bernards R, Rogelj S, Weinberg RA, Rapaport JM, Albert DM, Dryja TP. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. 1986;323:643-6. Nature.
Marees T, Moll AC, Imhof SM, de Boer MR, Ringens PJ, van Leeuwen FE. Risk Of Second Malignancies in Survivors of Retinoblastoma: More Than 40 Years of Follow up. J Natl Cancer Inst. 2008;100:1771-9.
Reiter A, Schrappe M, Parwaresch R, Henze G, Müller-Weihrich S, Sauter S, Sykora KW, Ludwig WD, Gadner H, Riehm H. Non Hodgkin's Lymphomas of Chilhood and Adolescence:Results of a Treatment Stratified For Biological Subtypes and Stage, Report of the Berlin-Frankfurt-Münster Group. J Clin Oncol. 1995;13:359-72.
Guérin S, Hawkins M, Shamsaldin A, Guibout C, Diallo I, Oberlin O, Brugières L, de Vathaire F. Treatment-Adjusted Predisposition to Second Malignant Neoplasms After a Solid Cancer in Childhood: A case-Control Study. J Clin Oncol. 2007;25:2833-2939.
Kleinerman RA, Tucker MA, Tarone RE, Abramson DH, Seddon JM, Stovall M, Li FP, Fraumeni JF Jr. Risk of New Cancers After Radiotherapy in Long - Term Survivors of Retinoblastoma:An Extended Follow up. J Clin Oncol. 2005;23:2272-9.
MacCarthy A, Bayne AM, Draper GJ, Eatock EM, Kroll ME, Stiller CA, Vincent TJ, Hawkins MM, Jenkinson HC, Kingston JE, Neale R, Murphy MF. Non-ocular Tumors Following Retinoblastoma in Great Britain 1951 to 2004.Br J Ophthalmol. 2009;93:1159-62.
Yu CL, Tucker MA, Abramson DH, Furukawa K, Seddon JM, Stovall M, Fraumeni JF Jr, Kleinerman RA. Cause Specific Mortality in Long Term Survivors of Retinoblastoma. J Natl Cancer Inst. 2009;101:581- 91.
Hongeng S, Parapakpenjun S, Pakakasama S, Rerkamnuaychoke B, Pornkul R. Second Burkitt Lymphoma in a Retinoblastoma Patient With 13q Deletion Syndrome. Pediatr Blood Cancer. 2006;46:524-6.
Ming-yan He, Yu An, Yi-jin Gao, Xiao-wen Qian, Gang Li, Jiang Qian. Screening of RB1 gene mutations in Chinese patients with retinoblastoma and preliminary exploration of genotype-phenotype correlations. Mol Vis. 2014;20:545-52.
Shields CL, Shields JA. Diagnosis and Management of Retinoblastoma. Cancer Control. 2004;11:317-27.