Bambang SETİAWAN, Nia KANİA, Edi WİDJAJANTO, M. Aris WİDODO, Sutiman B. SUMİTRO, HMS Chandra KUSUMA

Effects of Combined Inhalation of Coal Dust and Cigarette Smoking on Haematobiochemical Parameters

Amaç: Bu çalışmanın amacı, solunan kömür tozu partiküllerinin ve sigaranın, kömür analiz labaratuvarlarında çalışan işçilerin hematibiokimyasal profilleri üzerindeki etkisini saptamaktır. Materyal ve Metod: 29 işçi rastgele biçimde; kontrol (n=5),kömür tozuna maruz kalmış ancak sigara içmeyen (CDNS) (n=15) ve kömür tozuna maruz kalmış ve sigara içen (CDS) (n=9) olmak üzere üç gruba ayrılmıştır. Kontrol grubundaki bireyler idare ile ilgili birimde çalışan ve kömür tozuna maruz kalmayan bireylerden oluşmaktadır. Maruziyet grubundaki bireyler kömür tozu materyali ile çalışan bireyler olup sigara içen ve içmeyen olarak 2 gruba ayrılmıştır. Bireylerin kurumdaki çalışma süresi 10 yıldan azdır. Bulgular: Eozinofil ve monosit sayıları kontrol grupla karşılaştırıldığında kömür tozuna maruz kalan her 2 grupta da anlamlı şekilde azalmıştır (p < 0.05) . Segmental nötrofil sayıları kontrol grupla karşılaştırıldığında kömür tozuna maruz kalan her 2 grupta da anlamlı olarak artmıştır (p < 0.05). Eritrosit sedimentasyon oranı (ESR), kömür tozuna maruz kalmış ancak sigara içmeyen (CDNS) grupta kontrol grubuna göre anlamlı derecede azalmıştır (p < 0.05). Sonuç: Kömür Tozu solunması ile birlikte sigara içilmesi, eozinofil ve monosit sayısını azaltırken, segmental nötrofillerin sayısının artması gibi hücresel immün sistem mekanizmalarını değiştirmektedir. Bunun yanında bu maruziyet inflamasyonun akut fazınıda indüklemektedir.

Kömür Tozu Solunması ve Sigaranın Hematobiokimyasal Parametreler Üzerine Etkisi

Purpose: The aim of this study is to determine the effect of inhaled particulate matter coal dust and smoking on the haematobiochemical profile of worker in coal analysis laboratory. Material and Methods: Twenty nine workers, were randomly divided into three groups, one control group (n=5), one group who exposed to coal dust but non smoking (CDNS) (n=15), and one group exposed to coal dust and smoking (CDS) (n=9). The control group included subjects working in administrative division which none have been exposed to coal dust. Exposed group working on coal dust material analysis were divided as smokers and non smokers. The duration of their work period were less than 10 years. Results: Mean of eosinophil and monocytes counts were significantly lower in both of coal dust exposure compared to control group (p < 0.05). Segmental neutrophil counts were significant higher in coal dust exposure group with or without smoking compared to control group (p < 0.05). The level of erythocytre sedimentation rate (ESR) was significantly lower in CDNS group compared to control group (p < 0.05). Conclusion: Combined inhalation of coal dust and cigarette smoking changes cellular immune system such as decreasing of eosinophil and monocytes counts also increasing of segmental neutrophil. Beside that, this exposure also induces an acute phase process of inflammation.

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