Mangala HEGDE, Yousef Rezaei CHİANEH, Jeevan SHETTY, Donald J. FERNANDES, Pragna RAO

CA-125 and Ceruloplasmin Levels in Ovarian Cancer Patients

Amaç: Epitelial ovarian karsinomunda proliferasyonunun başlangıç aşaması genellikle asemptomatiktir. Hastaların büyük kısmında hassas ve güvenilir belirteçlerin eksikliği nedeni ile hastalık teşhis aşamasında artık yayılmış bulunmaktadır. Güvenilir olarak kabul edilen serum belirteci CA-125'tir ancak evre I hastalarının sadece %50'sinde ve ilerlemiş evre hastaların %80'ninde saptanabilmesinden dolayı, CA-125'in hassasiyeti konusunda bir sınırlama mevcuttur. Bu çalışmada, tedavi öncesi ve tedavi sonrası over kanserli hastalarda CA-125 ve seruloplazmin'in (anjiyogenez belirteci) serum seviyeleri arasındaki korelason araştırılmış, kontroller ile karşılaştırılmış ve teşhis için anlamlı bir belirteç olduğu bulunmuştur. Materyal ve Metod: Çalışma 18-45 yaş arası over kanseri teşhisi alan hastalar ile yapılmıştır (vaka n=50, kontrol n=50). Kanser teşhisi, biyopsi ve histopatolojik değerlendirme sonucu konulmuştur. Tedavi öncesi ve tedavi sonrası serum seruloplazmin ve CA-125 seviyeleri değerlendirilmiş ve tedavi öncesi ile karşılaştırıldığında, bu belirteçlerin tedavi sonrası hastalarda anlamlı derecede düştüğü gözlenmiştir. Sonuç: Serum CA-125 seruloplazmin oranı tedavi öncesi over kanserli hastalarda kısmen artmıştır. Serum seruloplazmin seviyesi (p

Over Kanserli Hastalarda CA-125 ve Seruloplazmin Düzeyleri

Purpose: The initial stage of proliferation of epithelial ovarian carcinoma (EOCa) is usually asymptomatic. Due to the lack of sensitive and reliable markers in majority of patients the disease is widespread at the time of diagnosis. The reliable serum biomarkers currently accepted is CA125 but there is limitation in case of sensitivity of CA125 as it is detectable only in 50% of patients in stage I and 80% of patients with advanced stage. We have investigated a correlation between serum CA125 and ceruloplasmin (as a marker of angiogenesis) in ovarian cancer in pre-treatment and post-treatment patients, compared with controls and found to be a significant marker for diagnosis. Material and Methods: A study was done in age group between 18-45 years diagnosed with ovarian cancer. (cases: n=50, controls: n=50). Cancer was diagnosed based on biopsy and histopathological examination. Serum Ceruloplasmin and CA 125 were estimated in pre-treatment and post-treatment patients and statistically significant decrease of these biomarkers observed in post treatment when compared with pre treatment patients. Result: We found that serum CA 125 to ceruloplasmin ratio was moderately increased in pre-treatment ovarian cancer patient. The serum ceruloplasmin (p

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