İlknur EROL, Yasemin ÖZKALE, Çağla SARITÜRK, Murat ÖZKALE

Association between platelet indices and febrile seizures in children

Amaç: Febril konvülziyon çocuklarda en sık görülen nöbet tipidir. Bu çalışmanın amacı çocuklarda trombosit belirteçleri ile febril konvülziyon arasındaki ilişkiyi incelemektir. Gereç ve Yöntem: Bu prospektif çalışmada febril konvülziyon ile başvuran 40 hasta ve kontrol grubu olarak nöbetsiz ateşli hastalık ile başvuran 30 hasta alındı. Febril konvülziyon ve ateşli hastalıkla başvuran her iki gruptada 1 saat ve 1 ay sonra trombosit sayısı, ortalama trombosit hacmi(MPV) ve trombosit dağılım genişliğini( PDW) içeren tam kan sayımına bakıldı. Bulgular: Bu çalışmada 1. saatin sonunda bakılan MPV ve PDW değerlerinin kompleks febril konvülziyon geçiren grupta basit febril konvülziyon geçiren gruba göre daha yüksek olduğunu bulurken 1. ayın sonunda iki grup arasında fark olmadığını bulduk. Ortalama trombosit sayısında basit ve kompleks febril konvülziyon geçiren gruplar arasında belirgin fark yoktu ama kompleks febril konvülziyon geçiren grupta daha düşük olarak bulduk. MPV ve PDW ile febril konvülziyon geçiren grupta orta derecede pozitif korelasyon varken, trombosit sayısı MPV ve PDW ile febril konvülziyon arasında orta derecede negatif korelasyon vardı. Sonuç: Bulgularımız kompleks febril konvülziyon hasta grubunda artmış trombosit döngüsünün trombosit sayısında düşüklüğe yol açtığını, belirgin olarak artan MPV ve PDW değerlerinin çocuklarda febril konvülziyonun şiddetini tahmin etmede önemli bir rol oynayabileceğini göstermektedir

Çocuklardatrombosit belirteçleri ve febril konvülziyon arasındaki ilişki

Purpose: Febrile seizures (FS) are the most common type of seizures in children.The aim of this study was to evaluate the relationship between platelet indices and FS in children. Materials and Methods: This prospective study included 40 children who presented with FS and 30 controls who presented with febrile illnesses without seizures. Complete blood counts, including platelet count (PC), mean platelet volume (MPV), and platelet distribution width (PDW) from both groups within 1 hour of FS and 1 month later were obtained. Results: We found that the MPV and PDW within 1 hour of seizure in children with complex FS group was higher than simple FS group while there was no significant difference in MPV and PDW between patients in the simple and complex FS groups at 1 month. The mean PC was not significantly different between simple and complex FS groups; but, we found that the mean PC in the complex FS group was slightly lower than simple FSgroup.There was a moderate significant positive correlation between MPV and PDW in children with FS while there was a moderate significant negative correlation between PC and MPV, PDW for FS . Conclusion: Our findings suggest that the increasing platelet turnover in complex FS group causes a slightly decrease in the PC, an significantly increase of MPV and PDW values indicating that these parameters may play an important role in predicting the severity of FS in children at diagnosis

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Hauser WA. The prevalence and incidence of convulsive disorders in children. Epilepsia. 1994;35:1-6.
Engel J. Report of the ILAE Classification Core Group. Epilepsia. 2006;47:1558-68.
French JA, Williamson PD, Thadani VM, Darcey TM, Mattson RH, Spencer SS et al. Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination. Ann Neurol. 1993;34:774- 80.
Sagar HJ, Oxbury JM. Hippocampal neuron loss in temporal lobe epilepsy: correlation with early childhood convulsions. Ann Neurol. 1987;22:334- 40.
Renshaw AA, Drago B, Toraya N, Gould EW. Respiratory syncytial virus infection is strongly correlated with decreased mean platelet volume. Int J Infect Dis. 2013;17:678-80.
Kapsoritakis AN, Koukourakis MI, Sfiridaki A, Potamianos SP, Kosmadaki MG, Koutroubakis IE et al.Mean platelet volume: a useful marker of inflammatory bowel disease activity. Am J Gastroenterol. 2001;96:776-81.
Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. 1996;7:157-61.
Ozaydin E, Arhan E, Cetinkaya B, Ozdel S, Değerliyurt A, Güven A et al.Differences in iron deficiency anemia and mean platelet volume between children with simple and complex febril seizures. Seizure. 2012;21:211-14.
Yavuz S, Ece A. Mean platelet volume as an indicator of disease activity in juvenile SLE. Clin Rheumatol. 2014;33:637-41.
Herve P, Humbert M, Sitbon O, Parent F, Nunes H, Legal C et al. hypertension: the role of platelets and thrombosis. Clin Chest Med. 2001;22:451-58.
Sakallı H, Kal O. Mean platelet volume as a potential predictor of proteinuria and amyloidosis in familial Mediterranean fever. Clin Rheumatol. 2013;32:1185- 190.
Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011;17:47-58.
Makay B, Türkyilmaz Z, Unsal E. Mean platelet volume in children with familial Mediterranean fever. Clin Rheumatol. 2009;28:975-78.
Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA et al. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine. 2008;75:291-94.
Choy M, Dubé CM, Ehrengruber M, Baram TZ. Inflammatory processes, febrile seizures, and subsequent 2014;14:15-22. Epilepsy Curr.
De Simoni MG, Perego C, Ravizza T, Moneta D, Conti M, Marchesi F et al. Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus. Eur J Neurosci. 2000;12:2623-633.
Vezzani A, Conti M, De Luigi A, Ravizza T, Moneta D, Marchesi F et al. Interleukin-1 beta immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional electrographic seizures. J Neurosci. 1999;19:5054- 065. enhancement of
Ravizza T, Balosso S, Vezzani A. Inflammation and prevention of epileptogenesis. Neurosci Lett. 2011;27;497:223-30.
Nur BG, Kahramaner Z, Duman O, Dundar NO, Sallakcı N, Yavuzer U et al. Interleukin-6 gene polymorphism in febrile seizures. Pediatr Neurol. 2012;46:36-38.
Uysal P, Tuncel T, Olmez D, Babayigit A, Karaman O, Uzuner N. The role of mean platelet volume predicting acute exacerbations of cystic fibrosis in children. Ann Thorac Med. 2011;6:227-30.
Yazici S, Yazici M, Erer B, Calik Y, Ozhan H, Ataoglu S. The platelet indices in patients with rheumatoid arthritis: mean platelet volume reflects disease activity. Platelets. 2010;21:122-25.
Ulasli SS, Ozyurek BA, Yilmaz EB, Ulubay G. Mean platelet volume as an inflammatory marker in acute exacerbation of chronic obstructive pulmonary disease. Pol Arch Med Wewn. 2012;122:284-90.
Becchi C, Al Malyan M, Fabbri LP, Marsili M, Boddi V, Boncinelli S. Mean platelet volume trend in sepsis: is it a useful parameter? Minerva Anestesiol. 2006;72:749-56.
Catal F, Bavbek N, Bayrak O, Uz E, Isik B, Karabel M et al. Platelet parameters in children with upper urinary tract infection: is there a specific response? Ren Fail. 2008;30:377-81.
Van der Lelie J, Von dem Borne AEG. Increased mean platelet volume in septicaemia. J Clin Pathol. 1983;36:693-96.
Robbins G, Barnard DL. Mean platelet volume changes in infection. J Clin Pathol. 1983;36:1320.
Catal F, Bavbek N, Bayrak O, Uz E, Isik B, Karabel M et al. Platelet parameters in children with upper urinary tract infection: is there a specific response? Ren Fail. 2008;3:377-81.
Van der Lelie J, Von dem Borne AK. Increased mean platelet volume in septicaemia. J Clin Pathol. 1983;36:693-96.
Emsley HC, Appleton RE,Whitmore CL, Jury F, Lamb JA, Martin JE et al. Variations in inflammation related genes may be associated with childhood febrile seizure susceptibility. Seizure. 2014;23:457-61.
Sibson NR, Blamire AM, Bernades-Silva M, Laurent S, Boutry S, Muller RN et al. MRI detection of early endothelial activation in brain inflammation. Magn Reson Med. 2004;51:248-52.