Akut miyokard infarktüsünde acil serviste saptanan stres hiperglisemi erken dönem mortalitesini gösteriyor
AMAÇ: Biz bu çalışmada acil servise başvuran akut miyokard infarktüsü (AMİ) hastalarının başvuru anındaki kan şekeri düzeyi ile kısa dönem prognozu arasında ilişkiyi araştırmayı amaçladık. GEREÇ ve YÖNTEM: Göğüs ağrısı ile başvuran ve AMİ tanısıyla Koroner Yoğun Bakıma yatırılan ardışık 100 hasta çalışmaya alındı. Acil servise başvuru anında alınan serum örnekleri incelendi, yatışları süresince izlenen aritmiler kaydedildi, gelişen mortaliteyi etkileyebilecek nedenler değerlendirildi ve kısa dönem mortalite oranları belirlendi. BULGULAR: Yatışları süresi içinde 14 (%14) hasta kaybedildi. Sadece DM olmayan hastalar incelendiğinde sağlıklı hastaların ortalama kan sekeri 158.8 ± 80.7 mg/dL iken kaybedilen hastalarda kan şekeri düzeyi 237.8 ± 115.5 mg/dL olarak saptandı (p
Stres hyperglycemia determined in emergency department predicts short term mortality in acute myocardial infarction
PURPOSE: We aimed to investigate the relationship between the initial serum glucose levels and short term prognosis of the patients with acute myocardial infarction (AMI) who were admitted to the Emergency Department (ED). METHODS: 100 patients who presented with angina pectoris and hospitalized with AMI diagnosis in the intensive care unit were included in the study. Their initial serum samples were detected, their arrhytmias during hospitalization period were recorded, the reasons which may effect their mortality were evaluated and short term mortality rates were determined. RESULTS: Fourteen patients (14%) died during their hospitalization periods. When non- diabetic patients were evaluated, while mean serum glucose levels in the dead patients were 237.8 ± 115.5 mg/dL, it was 158.8 ± 80.7 mg/dL in the survivors (p
___
- 1. Bellodi G, Manicardi V, Malavasi V et al. Hyperglycemia and prognosis of acute myocardial infarction in patients without diabetes mellitus. Am J Cardiol 1989;64:885-8.
- 2. Bolk J, Ploeg TVD, Cornel JH et al. Impaired glucose metabolism predicts mortality after a myocardial infarction. İnt J Cardiol 2001;79:207-14.
- 3. Chandalia HB, Gokani AH. Stress hyperglycemia. Lancet 1984;2:811-2.
- 4. Clarke RSJ, Johnston H, Sheridan B. The influence of anaesthesis and surgery on plasma cortisol, insulin and free fatty acids. Br J Anaesth 1970;42:295-99.
- 5. Grafeo CS. Hyperosmolar hyperglycemic nonketotic syndrome. In: Tintinallli JE, Kelen GD, Stapczynski JS.Emergency medicine. 5nd ed. Nort Carolina: McGraw Hill 2000. Pp 1340-3.
- 6. Malmberg K, Ryden L, Efendic S et al. Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI): effects on mortality at 1 year. J Am Coll Cardiol 1995;26;57-65.
- 7. Marfella R, Siniscalchi M, Esposito K et al. Effects of stress hyperglycemia on acute myocardial infarction: role of inflammatory immune process in functional cardiac outcome. Diabetes Care 2003;26:3129-35.
- 8. Meigs JB, Singer DE, Sullivan LM et al. Metabolic control and prevalent cardiovascular disease in noninsulin dependent diabetes mellitus (NIDDM): The NIDDM patient outcomes research team. Am J Med 1997;102:38-47.
- 9. Norhammar A, Tenerz A, Nilsson G et al.Glucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus : a prospective study. Lancet 2002;359:2140-4.
- 10. Oliver MF, Opie LH. Effects of glucose and fatty acids on myocardial ischemia and arrhythmias. Lancet 1994;343;155-8.
- 11. Reaven GM. Role of insulin resistance in human disease (Syndrome X): An expanded definition. Annu Rev Med 1993;44:12.
- 12. Silva JA, Escobar A, Collins TJ et al. Unstable angina. A comparison of angioscopic findings between diabetic and non-diabetic patients. Circulation. 1995 Oct 1;92(7):1731-6.
- 13. Stone PH, Muller JE, Hartwell T et al. The effect of diabetes mellitus on prognosis and serial left ventricular function after acute myocardial infarction: Contribution of both coronary disease and diastolic left ventricular dysfunction to the adverse prognosis. J Am Coll Cardiol 1989;14:49.
- 14. Tansey MJB, Opie LH. Plasma glucose on admission to hospital as a metabolic index of the severity of acute myocardial infarction. Can J Cardiol 1986;2:326-31.
- 15. Turner RC, Millns H, Neil A et al. Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom prospective diabetes study (UKPDS: 23). Br Med J 1998;316:823-8.
- 16. Vavuranakis M, Stefanadis C, Toutouzas K et al. Impaired compensatory coronary artery enlargement in atherosclerosis contributes to the development of coronary artery stenosis in diabetic patients. An in vivo intravascular ultrasound study. Eur Heart J. 1997 Jul;18(7):1090-4.
- 17. Weiss D. Hyperglycemia during physical stress. Am J Med 1996;00:374.