Serap UYSAL, Yücel TAŞTAN³, Zehra HASILOĞLU IŞIK, Mehmet Sait ALBAYRAM, Olcay ÜNVER, Sezgin ŞAHİN

Acute Necrotizing Encephalopathy of Childhood: A Turkish Case

Çocukluk çağının akut nekrotizan ensefalopatisi, talamusta tipik, simetrik lezyonlar ve ak madde, beyin sapı ve serebellumun değişken tutulumu ile nitelenen, etiyolojisi bilinmeyen, nadir bir akut ensefalittir. Klinikte, gastrointestinal veya solunum sistemini etkileyen nonspesifik viral enfeksiyonlar sonrasında hızlı nörolojik bozulma izlenir. Asya kökenli çocuklarda daha sık görülür. Üç yaşında bir erkek olgu bilinç bulanıklığı, ve ateş nedeniyle hastanemize başvurdu. Nazofarenks sürüntüsünde polimeraz zincir reaksiyonu ile insan parainfluenza virüs tip 2 saptandı. Beyin manyetik rezonans incelemesinde bilateral talamusta simetrik yayılan hiperintensiteler saptanan hastaya akut nekrotizan ensefalopati tanısı kondu.

Çocukluk Çağının Akut Nekrotizan Ensefalopatisi: Türkiye'den Bir Olgu

Acute necrotizing encephalopathy of childhood is a rare form of acute encephalopathy of unknown etiology characterized by typical symmetrical lesions in the thalami, with variable involvement of the white matter, brainstem and cerebellum. Clinically there is a rapid neurologic deterioration after a short period of a nonspecific viral-like illness associated with gastrointestinal or respiratory signs. Asian children are especially affected. Here we present a 3-yearold boy admitted to our hospital with fever and deterioration of consciousness. His nasopharyngeal swab for polymerase chain reaction revealed positive results for human parainfluenza 2 virüs. The diagnosis of acute necrotizing encephalopathy was made by cranial magnetic resonance imaging findings with symmetrical expansile hyperintense signals in bilateral thalami.

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