Gülşah Ünay, Havva Serap Toru, Hampar Akkaya, İsmail Türker Köksal, Bahar Akkaya

Yedi olguda mesanenin nöroendokrin tümörlerinin değerlendirilmesi

Bu çalışmada 2006-2014 yılları arasında Antalya bölgesinde iki merkezde tanı alan 690 mesane karsinomu içinden 7 tane nöroendokrin tümörün klinikopatolojik özellikleri sunularak tartışılmıştır. Her olgunun yaş, cinsiyet, başvuru semptomları, tümörün yerleşimi, klinik evresi, tedavi, takip ve sonuçları kaydedilmiştir. Çalışmamız mesanenin nöroendokrin karsinomlarının akciğerde görülenler gibi saldırgan ve çok kötü prognozlu olduğunu göstermiştir.

Evaluation of the neuroendocrine tumors of urinary bladder in seven cases

In this study we reviewed 7 neuroendocrine tumors of bladder among 690 bladder carcinomas with their clinicopathologic characteristics diagnosed in Antalya region, in two medical centers. In each case, the following clinical data were recorded: age, sex, presenting symptoms, location of the tumor, clinical staging, treatment, follow-up and outcome. This study indicates that neuroendocrine carcinoma of the urinary bladder is as aggressive as its pulmonary counterpart and the overall prognosis of this tumor is very poor.

Keywords:

: Bladder carcinoma, neuroendocrine, small cell carcinoma,

PDF

___

Citgez S, Erözenci A, Yörükoğlu K. Non-ürotelyal mesane kanserleri. Üroonkoloji Bülteni. 2007;4:9-14.
Yıkılmaz TN, Bas O, Arık AI, Hızlı F, Başar H. Mesanenin nadir görülen kanserleri: olgu serisi ve literatürün gözden geçirilmesi, Dicle Tıp Dergisi, 2014;41:767-72.
Dahm P, Gschwend JE. Malignant non-urothelial neoplasms of the urinary bladder: a review. Eur Urol. 2003;44:672-81.
Zhao X, Flynn EA. Small cell carcinoma of the urinary bladder: a rare, aggressive neuroendocrine malignancy. Arch Pathol Lab Med.2012;136:1451-9.
Nabil İsmaili. A rare bladder cancer – small cell carcinoma: review and update. Orphanet J Rare Dis. 2011;13, 6:75.
Eble JN , Sauter G, Epstein JI, Sesterhenn IA. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. Lyon, IARC Press, 2004.
Vincendeau S, de Lajarte-Thirouard AS, Bensalah K, Guillé F, Lobel B, Patard JJ. Neuroendocrine differentiation of bladder tumors. Prog Urol. 2003;13:375-84.
Lee KH, Ryu SB, Lee MC, Park CS, Juhng SW, Choi C. Primary large cell neuroendocrine carcinoma of the urinary bladder. Pathol Int. 2006;56:688-93.
Çallı AO, Uyaroğlu MA, Sarı A, Ermete M, Bal K. Mesanenin küçük hücreli kanseri: Olgu sunumu. Türk Üroloji Dergisi. 2005;31:596-8.
Lopez JI, Angulo JC, Flores N, Toledo JD. Small cell carcinoma of the urinary bladder. A clinicopathological study of six cases. Br J Urol. 1994;73:43-9.
Gon S, Majumdar B, Dey RK, Mitra SK. Pure primary small cell carcinoma of urinary bladder: A rare diagnostic entity. Urol Ann. 2013;5:209-11.
Karpman E, Goldberg Z, Saffarian A, Gandour- Edwards R, Ellison LM, de Vere White RW. Analysis of treatment for small cell cancer of the bladder and report of three cases. Urology. 2004;64:494-8.
Trias I, Algaba F, Condom E, Español I, Seguí J, Orsola I et al. Small cell carcinoma of the urinary bladder. Presentation of 23 cases and review of 134 published cases. Eur Urol. 2001;39:85-90.
Mukesh M, Cook N, Hollingdale AE, Ainsworth NL, Russell SG. Small cell carcinoma of the urinary bladder: a 15-year retrospective review of the treatment and survival in the Anglian Cancer Network. BJU Int. 2009;103:747-52.
Blomjous CE, Vos W, De Voogt HJ, Van der Valk P, Meijer CJ. Small cell carcinoma of the urinary bladder: immunohistochemical and ultrastructural study of 18 cases. Cancer. 1989;64:1347-57. morphologic,
Ali SZ, Reuter VE, Zakowski MF. Small cell neuroendocrine carcinoma of the urinary bladder: A clinicopathologic study with emphasis on cytologic features. Cancer. 1997;79:356-61.
İbrahim NJ, Briggs JC, and CM, Extrapulmonary oat cell carcinoma. Cancer. 1984;54:1645-61.
Lohrisch C, Murray N, Pickles T, Sullivan L. Small cell carcinoma of the bladder: long term outcome with 1999;86:2346-52. Cancer.
Siefker-Radtke AO, Dinney CP, Abrahams NA, Moran C, Shen Y, Pisters LL et al. Evidence supporting preoperative chemo-therapy for small cell carcinoma of the bladder: a retrospective review of the M. D. Anderson cancer experience. J Urol. 2004;172:481-4.
Holmang S, Borghede G, Johansson SL. Primary small cell carcinoma of the bladder: a report of 25 cases. J Urol. 1995;153:1820-2.
Bastus R, Caballero JM, Gonzalez G, Borrat P, Casalots J, Gomez de Segura G et al. Small cell carcinoma of the urinary bladder treated with chemotherapy and radiotherapy: Results in five cases. Eur Urol. 1999;35:323-6.
Grignon DJ, Ro JY, Ayala AG, Shum DT, Ordóñez NG, Logothetis CJ et al. Small cell carcinoma of the urinary bladder. A clinicopathologic analysis of 22 cases. Cancer. 1992;69:527-36.