Yaygın anksiyete bozukluğu olan hastalarda arteriyel sertliğin değerlendirilmesi

Amaç: Yaygın anksiyete bozukluğu (YAB) sempatik sistemin aktive olmasıyla birlikte bedensel ve ruhsal belirtilerin bir arada görüldüğü psikiyatrik hastalıktır. Bu hastalıkta kardiyovasküler sistemin etkilendiği bilinmektedir. Bu çalışmada YAB tanılı hastalarda arter sertliğini değerlendirmeyi ve sağlıklı kontrollerle kıyaslamayı amaçladık. Gereç ve Yöntem: YAB tanısı almış 40 hasta ve 40 sağlıklı birey çalışmaya dahil edildi. Karotis ve femoral arter intima-medial kalınlığı (IMT) ve arteriyel kalınlık parametreleri doppler ultrasonografi ile ölçüldü. Bulgular: Hastaların femoral IMT değeri anlamlı şekilde düşük bulunmuştur. Hastalarda carotid IMT değeri ise sağlıklılardan daha kalın olmasına rağmen bu fark istatistiksel olarak anlamlı değildi. Fluoksetin eş değer dozu ile femoral IMT arasında negatif yönde anlamlı bir korelasyon belirlenmiştir. Femoral IMT ile fluoksetin eş değer dozu arasında ilişki olduğu görülmüştür. Sonuç: Arteriyel sertlik YAB' da kardiyovasküler riski gösterebilme potansiyeli açısından araştırılmalıdır. Ateroskleroz belirtilerinin YAB hastalığının doğası gereği mi yoksa kullanılan ilaçlarla ilişkili mi olduğunu netleştirebilmek için daha geniş kapsamlı çalışmalara ihtiyaç bulunmaktadır.

Anahtar Kelimeler:

Arteriyrl sertlik, yaygın anksiyete bozukluğu, kardiyovasküler risk, intima–media kalınlığı

Evaluation of arterial stiffness in patients with generalized anxiety disorder

Purpose: Generalized anxiety disorder (GAD) is a psychiatric condition where both physical and mental symptoms are observed due to the activation of the sympathetic system. It is known that the disorder affects the cardiovascular system. The present study aimed to analyze arterial stiffness in GAD patients and compare the findings with healthy controls. Materials and Methods: 40 patients diagnosed with GAD and 40 healthy individuals were included in the study. Carotid and femoral artery intima-medial thickness (IMT) and arterial thickness parameters were measured with Doppler ultrasonography. Results: The femoral IMT of the patients was significantly low. Although the carotid IMT was higher in patients when compared to the controls, the difference was not statistically significant. A significant negative correlation was determined between fluoxetine equivalent dose and femoral IMT. There was a correlation between femoral IMT and fluoxetine equivalent dose. Conclusion: Arterial stiffness should be investigated for its potential to indicate cardiovascular risk in GAD. Further comprehensive studies should be conducted to clarify whether atherosclerosis symptoms were associated with the nature of the GAD or prescription medicine.

Keywords:

Arterial stiffness, generalized anxiety disorder, cardiovascular risk, intima–media thickness.,

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