Üstün SEZER, Rahşan Dilek OKYAY, Hilal AYOĞLU, Bengü Gülhan KÖKSAL, Gamze KÜÇÜKOSMAN, Özcan PİŞKİN, Nilay Nur GENÇOĞLU, Ferruh AYOĞLU, Fikret ÇINAR, Işıl ÖZKOÇAK TURAN

TİVA ile inhalasyon anestezi yöntemlerinin koku fonksiyonlarına ve koku hafızası üzerine etkisinin karşılaştırılması: randomize prospektif bir çalışma

Amaç: Bu çalışmada, farklı genel anestezi uygulamalarının postoperatif koku fonksiyonları ve koku hafızası üzerine olan etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Bu çalışma prospektif olarak 97 hasta ile yapıldı. Hastalar anestezi indüksiyonu ve idame yöntemine göre üç gruba ayrıldı; Grup P (propofol ile indüksiyon ve idame), Grup PS (propofol ile indüksiyon, sevofluran ile idame), Grup S (sevofluran ile indüksiyon ve idame). Butanol eşik ve koku identifikasyon testleri ameliyattan 30 dakika (dk) önce (bazal=T1), ameliyattan 30 dk (T2), 8 saat (s) (T3) ve 24 s sonra (T4) uygulandı. Bulgular: Tüm gruplarda butanol eşik testi değerlerinin bazale göre T2 zamanında arttığı ve bu artışın sadece Grup P'de T3’te bazale döndüğü gözlendi. Butanol eşik testi değerleri açısından Grup P ile Grup S arasında, T1 hariç tüm zamanlarda anlamlı farklılık saptandı. Koku identifikasyonunun Grup P'de bazale göre T3 ve T4’de arttığı, Grup P ile karşılaştırıldığında ise; Grup S’de T2, T3 ve T4, Grup PS’de ise T2 ve T3 arasında anlamlı farklılık olduğu gözlendi. Sonuç: Propofolün sadece erken dönemde koku fonksiyonlarında geçici bir bozukluğa sebep olur.

Anahtar Kelimeler:

Koku işlevi, Propofol, Sevofluran, Koku hafızası

Comparison of the effects of TIVA and inhalation anesthetic techniques on olfactory functions and olfactory memory: a randomized prospective study

Purpose: This study aimed to investigate the effects of different general anesthesia procedures on postoperative olfactory functions and olfactory memory. Materials and Methods: This prospective study was conducted with 97 patients. Patients were divided into three groups based on anesthesia induction and maintenance technique: Group P (induction and maintenance with propofol), Group PS (induction with propofol, maintenance with sevoflurane), and Group S (induction with sevoflurane, maintenance with sevoflurane). Butanol threshold and olfactory identification tests were administered 30 minutes (min) before the operation (T1) and 30 min (T2), 8 hours (h) (T3) and 24 h (T4) after the operation. Results: Butanol threshold values were increased at the T2 time point compared to baseline in all groups, which returned to baseline values at T3 only in Group P. There was a significant difference between Group P and Group S in terms of butanol threshold values at all time points except T1. When olfactory identification increased at T3 and T4 compared to baseline in Group P, there was a significant difference between T2, T3, and T4 time points in Group S, and between T2 and T3 time points in Group PS as compared to Group P. Conclusion: Propofol only causes a temporary impairment in olfactory functions in the early period and does not alter olfactory memory.

Keywords:

Propofol, Sevoflurane, Olfactory functions, Olfactory memory,

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