Mangala HEGDE, Yousef CHİANEH, Jeevan SHETTY, Donald J FERNANDES, Pragna RAO

Over Kanserli Hastalarda CA-125 ve Seruloplazmin Düzeyleri

Amaç: Epitelial ovarian karsinomunda proliferasyonunun başlangıç aşaması genellikle asemptomatiktir. Hastaların büyük kısmında hassas ve güvenilir belirteçlerin eksikliği nedeni ile hastalık teşhis aşamasında artık yayılmış bulunmaktadır. Güvenilir olarak kabul edilen serum belirteci CA-125’tir ancak evre I hastalarının sadece %50’sinde ve ilerlemiş evre hastaların %80’ninde saptanabilmesinden dolayı, CA-125’in hassasiyeti konusunda bir sınırlama mevcuttur. Bu çalışmada, tedavi öncesi ve tedavi sonrası over kanserli hastalarda CA-125 ve seruloplazmin’in (anjiyogenez belirteci) serum seviyeleri arasındaki korelason araştırılmış, kontroller ile karşılaştırılmış ve teşhis için anlamlı bir belirteç olduğu bulunmuştur. Materyal ve Metod: Çalışma 18-45 yaş arası over kanseri teşhisi alan hastalar ile yapılmıştır (vaka n=50, kontrol n=50). Kanser teşhisi, biyopsi ve histopatolojik değerlendirme sonucu konulmuştur. Tedavi öncesi ve tedavi sonrası serum seruloplazmin ve CA-125 seviyeleri değerlendirilmiş ve tedavi öncesi ile karşılaştırıldığında, bu belirteçlerin tedavi sonrası hastalarda anlamlı derecede düştüğü gözlenmiştir. Sonuç: Serum CA-125 seruloplazmin oranı tedavi öncesi over kanserli hastalarda kısmen artmıştır. Serum seruloplazmin seviyesi (p<0.0001) kontrollerle karşılaştırıldığında over kanserli hastalarda anlamlı olarak yüksek bulunmştur. Tartışma: Seruloplazmin ve CA-125’in serumdaki seviyeleri tedaviden sonra azalmaktadır, buna bağlı olarak kanser tanı ve tedavisinde yeni tedavi stratejilerinin geliştirilmesinde güvenli ve etkili olabileceği düşünülmektedir.

Anahtar Kelimeler:

Epitelial Over Karsinom, Seruloplasmin, Karbohidrat antijen 125 (CA-125)

CA-125 and Ceruloplasmin Levels in Ovarian Cancer Patients

Purpose: The initial stage of proliferation of epithelial ovarian carcinoma (EOCa) is usually asymptomatic. Due to the lack of sensitive and reliable markers in majority of patients the disease is widespread at the time of diagnosis. The reliable serum biomarkers currently accepted is CA125 but there is limitation in case of sensitivity of CA125 as it is detectable only in 50% of patients in stage I and 80% of patients with advanced stage. We have investigated a correlation between serum CA125 and ceruloplasmin (as a marker of angiogenesis) in ovarian cancer in pre-treatment and post-treatment patients, compared with controls and found to be a significant marker for diagnosis. Material and Methods: A study was done in age group between 18-45 years diagnosed with ovarian cancer. (cases: n=50, controls: n=50). Cancer was diagnosed based on biopsy and histopathological examination. Serum Ceruloplasmin and CA 125 were estimated in pre-treatment and post-treatment patients and statistically significant decrease of these biomarkers observed in post treatment when compared with pre treatment patients. Result: We found that serum CA 125 to ceruloplasmin ratio was moderately increased in pre-treatment ovarian cancer patient. The serum ceruloplasmin (p<0.0001) level was significantly increased in ovarian cancer patients as compared to controls. Conclusion: Serum ceruloplasmin as well CA-125 level decline after treatment, and have been associated with efficacy and safety of novel therapeutic strategy to improve diagnosis and treatment for cancer

Keywords:

Epithelial ovarian carcinoma (EOCa), Ceruloplasmin, Carbohydrate antigen 125 (CA-125),

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