Kan eozinofil-bazofil oranı, eozinofil-lenfosit oranı ve bazofil-lenfosit oranı değerleri gebelikteki intrahepatik kolestazın şiddetini tahmin edebilir mi?

Amaç: Alerjik hastalıklar için kullanılan inflamatuvar belirteçler ile intrahepatik gebelik kolestazı (ICP) arasındaki ilişkiyi araştırmayı amaçladık. Gereç ve Yöntem: Bu retrospektif vaka-kontrol çalışmasına 87si hafif kolestazlı (grup 1) ve 27si şiddetli kolestazlı (grup 2) olmak üzere toplam 114 intrahepatik gebelik kolestazlı hasta ve kontrol grubunda 292 sağlıklı gebe (grup 3) çalışmaya dahil edildi. Bu çalışmada kullanılan bazofil, eozinofil, eozinofil-bazofil oranı (EBO), eozinofil-lenfosit oranı (ELO) ve bazofil-lenfosit oranı (BLO), nötrofi-lenfosit oranı (NLO) ve platelet-lenfosit oranı (PLO) değerleri herhangi bir tıbbi veya cerrahi işlem başlatılmadan önce alınan kanlardan değerlendirilmiştir. Bulgular: ELO, NLO ve PLO değerleri açısından gruplar arasında anlamlı bir fark olduğu saptandı. ELO, NLO, PLO değerleri hafif kolestaz grubunda kontrol grubuna göre anlamlı olarak daha yüksekti. Gebelik kolestazını tahmin etmek için, alıcı işletim karakteristik eğrisi (ROC) analizi kullanıldı. ELO'nın kesme değeri 0,2243 olduğu zaman %76,3 duyarlılık ve %56,1 özgüllük, NLO kesme değeri 11.27 olduğu zaman duyarlılığı 70% ve özgüllük 54,2%, PLO kesme değeri 194,46 olduğu zaman duyarlılığı 60% ve özgüllük 58%olarak saptandı. Sonuç: Serum inflamasyon belirteçleri ve alerji belirteçleri intrahepatik gebelik kolestazda tanı koydurucu olabilir ancak hastalığın şiddetini saptamada belirleyici değildir.

Can blood eosinophil to basophil ratio, eosinophil to lymphocyte ratio and basophil to lymphocyte ratio predict the severity of intrahepatic cholestasis in pregnancy?

Purpose: The purpose of the study was to investigate the relation between inflammatory markers used for allergic diseases and intrahepatic pregnancy cholestasis (ICP). Materials and Methods: In this retrospective case-control study, a total of 114 intrahepatic pregnancy cholestasis patients; 87 with mild cholestasis (group 1) and 27 with severe cholestasis (group 2) and 292 healthy pregnant women in the control group (group 3) were included in the study. The basophil, eosinophil, eosinophil-basophil ratio (EBR), eosinophil-lymphocyte ratio (ELR) and basophil-lymphocyte ratio (BLR), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) values used in this study. Results: Significant differences were detected between groups in terms of ELR, NLR and PLR values. ELR, NLR, PLR values were significantly higher in the mild cholestasis group than in the control group. To predict the pregnancy cholestasis, receiver operating characteristic curve (ROC) analysis was made, which yielded 76.3% sensitivity and 56.1% specificity when ELR’s interrupt value was 0.2243, NLR interrupt value 11.27% when sensitivity was 70% and specificity 54,000 2%, and PLR cut-off value was 194.46 when sensitivity was 60% and specificity was 58%. Conclusion: Serum inflammation markers and allergy markers may be diagnostic in intrahepatic pregnancy cholestasis; however, they are not decisive in determining the severity of the disease.

Keywords:

Intrahepatic cholestasis pregnancy, allergy markers,

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